Clinicopathological and Molecular Features of Patients with Early and Late Recurrence after Curative Surgery for Colorectal Cancer.
colorectal cancer
early recurrence
genetic alteration
late recurrence
prognostic factor
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
14 Apr 2021
14 Apr 2021
Historique:
received:
05
03
2021
revised:
10
04
2021
accepted:
12
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Few reports have investigated genetic alterations between patients with early and late recurrence following curative surgery for colorectal cancer (CRC). A total of 1227 stage I-III CRC patients who underwent curative resection were included retrospectively. Among them, 236 patients had tumor recurrence: 139 had early (<2 years after surgery) and 97 had late (≥2 years after surgery) recurrence. Clinicopathological features and genetic alterations were compared between the two groups. Compared to those with late recurrence, patients with early recurrence were more likely to have advanced pathological node (N) categories; tumor, node, metastasis (TNM) stages; adjuvant chemotherapy treatment; liver metastases; CRC patients with early recurrence have a worse OS rate and more
Sections du résumé
BACKGROUND
BACKGROUND
Few reports have investigated genetic alterations between patients with early and late recurrence following curative surgery for colorectal cancer (CRC).
METHODS
METHODS
A total of 1227 stage I-III CRC patients who underwent curative resection were included retrospectively. Among them, 236 patients had tumor recurrence: 139 had early (<2 years after surgery) and 97 had late (≥2 years after surgery) recurrence. Clinicopathological features and genetic alterations were compared between the two groups.
RESULTS
RESULTS
Compared to those with late recurrence, patients with early recurrence were more likely to have advanced pathological node (N) categories; tumor, node, metastasis (TNM) stages; adjuvant chemotherapy treatment; liver metastases;
CONCLUSION
CONCLUSIONS
CRC patients with early recurrence have a worse OS rate and more
Identifiants
pubmed: 33919924
pii: cancers13081883
doi: 10.3390/cancers13081883
pmc: PMC8070938
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Taipei Veterans General Hospital
ID : V105C-043, V106C-027, V107C-004
Organisme : Ministry of Science and Technology, Taiwan
ID : 105-2314-B-075-010-MY2
Organisme : Taipei City Hospital
ID : 10601-62-059,10701-62-050
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