Could Antigen Presenting Cells Represent a Protective Element during SARS-CoV-2 Infection in Children?
Antigen Presenting Cells (APC)
COVID-19
IFN-signaling
SARS-CoV-2
cytokine storm
juvenile immunity
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
14 Apr 2021
14 Apr 2021
Historique:
received:
01
03
2021
revised:
06
04
2021
accepted:
10
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Antigen Presenting Cells (APC) are immune cells that recognize, process, and present antigens to lymphocytes. APCs are among the earliest immune responders against an antigen. Thus, in patients with COVID-19, a disease caused by the newly reported SARS-CoV-2 virus, the role of APCs becomes increasingly important. In this paper, we dissect the role of these cells in the fight against SARS-CoV-2. Interestingly, this virus appears to cause a higher mortality among adults than children. This may suggest that the immune system, particularly APCs, of children may be different from that of adults, which may then explain differences in immune responses between these two populations, evident as different pathological outcome. However, the underlying molecular mechanisms that differentiate juvenile from other APCs are not well understood. Whether juvenile APCs are one reason why children are less susceptible to SARS-CoV-2 requires much attention. The goal of this review is to examine the role of APCs, both in adults and children. The molecular mechanisms governing APCs, especially against SARS-CoV-2, may explain the differential immune responsiveness in the two populations.
Identifiants
pubmed: 33920011
pii: pathogens10040476
doi: 10.3390/pathogens10040476
pmc: PMC8071032
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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