Epilepsy as a Comorbidity in Polymyositis and Dermatomyositis-A Cross-Sectional Study.


Journal

International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455

Informations de publication

Date de publication:
10 04 2021
Historique:
received: 07 03 2021
revised: 04 04 2021
accepted: 06 04 2021
entrez: 30 4 2021
pubmed: 1 5 2021
medline: 22 5 2021
Statut: epublish

Résumé

Polymyositis (PM) and dermatomyositis (DM) are autoimmune-mediated multisystemic myopathies, characterized mainly by proximal muscle weakness. A connection between epilepsy and PM/DM has not been reported previously. Our study aim is to evaluate this association. A case-control study was conducted, enrolling a total of 12,278 patients with 2085 cases (17.0%) and 10,193 subjects in the control group (83.0%). Student's t-test was used to evaluate continuous variables, while the chi-square test was applied for the distribution of categorical variables. Log-rank test, Kaplan-Meier curves and multivariate Cox proportional hazards method were performed for the analysis regarding survival. Of the studied 2085 cases, 1475 subjects (70.7%) were diagnosed with DM, and 610 patients (29.3%) with PM. Participants enrolled as cases had a significantly higher rate of epilepsy (

Identifiants

pubmed: 33920065
pii: ijerph18083983
doi: 10.3390/ijerph18083983
pmc: PMC8068784
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Ella Nissan (E)

Department of Medicine 'B' & Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 5262000, Israel.
Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel.

Abdulla Watad (A)

Department of Medicine 'B' & Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 5262000, Israel.
Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel.

Arnon D Cohen (AD)

Chief Physician's Office, Clalit Health Services, Tel Aviv 16250, Israel.
Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8489325, Israel.

Kassem Sharif (K)

Department of Medicine 'B' & Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 5262000, Israel.
Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel.

Johnatan Nissan (J)

Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel.
Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer 5262000, Israel.

Howard Amital (H)

Department of Medicine 'B' & Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 5262000, Israel.
Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel.

Ora Shovman (O)

Department of Medicine 'B' & Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 5262000, Israel.
Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel.

Nicola Luigi Bragazzi (NL)

Laboratory for Industrial and Applied Mathematics (LIAM), Department of Mathematics and Statistics, York University, Toronto, ON M3J 1P3, Canada.

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