Comparison of Clinical, Laboratory and Immune Characteristics of the Monophasic and Biphasic Course of Tick-Borne Encephalitis.

adaptive immune responses biphasic course cerebrospinal fluid chemokines cytokines innate immune responses long-term outcome monophasic course tick-borne encephalitis

Journal

Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893

Informations de publication

Date de publication:
10 Apr 2021
Historique:
received: 26 03 2021
revised: 08 04 2021
accepted: 08 04 2021
entrez: 30 4 2021
pubmed: 1 5 2021
medline: 1 5 2021
Statut: epublish

Résumé

The biphasic course of tick-borne encephalitis (TBE) is well described, but information on the monophasic course is limited. We assessed and compared the clinical presentation, laboratory findings, and immune responses in 705 adult TBE patients: 283 with monophasic and 422 with biphasic course. Patients with the monophasic course were significantly (

Identifiants

pubmed: 33920166
pii: microorganisms9040796
doi: 10.3390/microorganisms9040796
pmc: PMC8070281
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Slovenian Research Agency
ID : P3-0296, J3-1744, and J3-8195
Organisme : NIH HHS
ID : R21 AI144916
Pays : United States

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Auteurs

Petra Bogovič (P)

Department of Infectious Diseases, University Medical Centre Ljubljana, Japljeva 2, 1525 Ljubljana, Slovenia.
Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

Stanka Lotrič-Furlan (S)

Department of Infectious Diseases, University Medical Centre Ljubljana, Japljeva 2, 1525 Ljubljana, Slovenia.
Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

Tatjana Avšič-Županc (T)

Faculty of Medicine, Institute for Microbiology and Immunology, University of Ljubljana, Zaloška 4, 1000 Ljubljana, Slovenia.

Miša Korva (M)

Faculty of Medicine, Institute for Microbiology and Immunology, University of Ljubljana, Zaloška 4, 1000 Ljubljana, Slovenia.

Andrej Kastrin (A)

Faculty of Medicine, Institute for Biostatistics and Medical Informatics, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

Lara Lusa (L)

Faculty of Medicine, Institute for Biostatistics and Medical Informatics, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.
Department of Mathematics, Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Glagoljaška 8, 6000 Koper, Slovenia.

Klemen Strle (K)

Laboratory of Microbial Pathogenesis and Immunology, Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA.

Franc Strle (F)

Department of Infectious Diseases, University Medical Centre Ljubljana, Japljeva 2, 1525 Ljubljana, Slovenia.

Classifications MeSH