The Eyes Absent Proteins: Unusual HAD Family Tyrosine Phosphatases.
EYA
EYA1
EYA2
EYA3
EYA4
HAD
PTP
eyes absent
tyrosine phosphatase
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Apr 2021
10 Apr 2021
Historique:
received:
12
02
2021
revised:
30
03
2021
accepted:
03
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
14
5
2021
Statut:
epublish
Résumé
Here, we review the haloacid dehalogenase (HAD) class of protein phosphatases, with a particular emphasis on an unusual group of enzymes, the eyes absent (EYA) family. EYA proteins have the unique distinction of being structurally and mechanistically classified as HAD enzymes, yet, unlike other HAD phosphatases, they are protein tyrosine phosphatases (PTPs). Further, the EYA proteins are unique among the 107 classical PTPs in the human genome because they do not use a Cysteine residue as a nucleophile in the dephosphorylation reaction. We will provide an overview of HAD phosphatase structure-function, describe unique features of the EYA family and their tyrosine phosphatase activity, provide a brief summary of the known substrates and cellular functions of the EYA proteins, and speculate about the evolutionary origins of the EYA family of proteins.
Identifiants
pubmed: 33920226
pii: ijms22083925
doi: 10.3390/ijms22083925
pmc: PMC8069645
pii:
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Nuclear Proteins
0
Hydrolases
EC 3.-
EYA1 protein, human
EC 3.1.3.48
Protein Tyrosine Phosphatases
EC 3.1.3.48
2-haloacid dehalogenase
EC 3.8.1.2
Cysteine
K848JZ4886
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R01 CA207068
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL152094
Pays : United States
Organisme : NCI NIH HHS
ID : CA207068
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL152094
Pays : United States
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