Sinapic Acid Suppresses SARS CoV-2 Replication by Targeting Its Envelope Protein.
COVID-19
SARS CoV-2
molecular dynamic simulation
sinapic acid
viral envelope protein
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
11 Apr 2021
11 Apr 2021
Historique:
received:
17
03
2021
revised:
07
04
2021
accepted:
09
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
SARS CoV-2 is still considered a global health issue, and its threat keeps growing with the emergence of newly evolved strains. Despite the success in developing some vaccines as a protective measure, finding cost-effective treatments is urgent. Accordingly, we screened a number of phenolic natural compounds for their in vitro anti-SARS CoV-2 activity. We found sinapic acid (SA) selectively inhibited the viral replication in vitro with an half-maximal inhibitory concentration (IC
Identifiants
pubmed: 33920366
pii: antibiotics10040420
doi: 10.3390/antibiotics10040420
pmc: PMC8069661
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : the Saudi Ministry of Health, Kingdom of Saudi Arabia
ID : contract number 11492700006 - project number 492
Références
Chem Soc Rev. 2021 Mar 21;50(6):3647-3655
pubmed: 33524090
Viruses. 2020 Mar 31;12(4):
pubmed: 32244383
J Mol Graph. 1996 Feb;14(1):33-8, 27-8
pubmed: 8744570
J Comput Aided Mol Des. 2010 May;24(5):417-22
pubmed: 20401516
ACS Pharmacol Transl Sci. 2020 Jul 30;3(5):813-834
pubmed: 33062950
Microorganisms. 2020 Jun 29;8(7):
pubmed: 32610445
Plants (Basel). 2020 Dec 26;10(1):
pubmed: 33375282
J Comput Chem. 2008 Aug;29(11):1859-65
pubmed: 18351591
Arch Virol. 2003 Nov;148(11):2207-35
pubmed: 14579179
Antibiotics (Basel). 2020 Aug 31;9(9):
pubmed: 32878266
Plant Foods Hum Nutr. 2018 Jun;73(2):95-100
pubmed: 29675806
Ann Clin Microbiol Antimicrob. 2020 May 30;19(1):23
pubmed: 32473642
ACS Infect Dis. 2020 Sep 11;6(9):2524-2531
pubmed: 32786284
Nature. 2020 Jul;583(7816):459-468
pubmed: 32353859
IUCrJ. 2020 Jul 17;7(Pt 5):814-824
pubmed: 32939273
Front Pharmacol. 2021 Mar 19;12:649532
pubmed: 33815126
J Biomol Struct Dyn. 2020 Dec 15;:1-11
pubmed: 33317409
J Agric Food Chem. 2008 Nov 12;56(21):10265-72
pubmed: 18841975
Acta Pharmacol Sin. 2020 Sep;41(9):1167-1177
pubmed: 32737471
J Immunol Methods. 1983 Dec 16;65(1-2):55-63
pubmed: 6606682
Pharmaceuticals (Basel). 2021 Mar 04;14(3):
pubmed: 33806331
J Comput Chem. 2005 Dec;26(16):1781-802
pubmed: 16222654
PLoS One. 2021 Feb 16;16(2):e0247163
pubmed: 33592050
Nat Struct Mol Biol. 2020 Dec;27(12):1202-1208
pubmed: 33177698
Virology. 2006 Sep 30;353(2):294-306
pubmed: 16815524
Antiviral Res. 2020 Jun;178:104787
pubmed: 32251768
Nat Prod Res. 2020 Oct 30;:1-5
pubmed: 33121282
PLoS Pathog. 2009 Jul;5(7):e1000511
pubmed: 19593379
J Agric Food Chem. 2013 Dec 11;61(49):12053-9
pubmed: 24261449
Glob Chall. 2017 Jan 10;1(1):33-46
pubmed: 31565258
Biol Pharm Bull. 2007 Mar;30(3):514-9
pubmed: 17329848