Preoperative Inflammatory Markers as a Predictor of Three-Year Overall Survival in Older Cancer Patients Undergoing Oncologic Surgery.
cancer
inflammatory response
older patients
preoperative inflammatory markers
survival
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
11 Apr 2021
11 Apr 2021
Historique:
received:
22
02
2021
revised:
03
04
2021
accepted:
08
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Oncologic surgery results in substantially higher morbidity and mortality rates in older patients compared to younger patients, yet little is known about the relation between the preoperative inflammatory state and postoperative outcome in the specific group of older cancer patients. The aim of this study was to examine whether preoperative inflammatory markers could be a predictor of overall survival in older patients undergoing elective surgery for a solid malignant tumor. Patients 65 years and older undergoing surgery for a solid malignant tumor were included in a prospective cohort study. Inflammatory markers C-reactive protein (CRP), interleukin-1 beta (IL-1β), IL-6, IL10, IL-12 and tumor necrosis factor-alpha (TNF-α) were measured in plasma samples preoperatively. The main outcome was overall survival three years after surgery. Between 2010 and 2016, 328 patients with a median age of 71.5 years (range 65-89) were included. A significantly higher mortality rate three years after surgery, was found in patients with high preoperative plasma levels of CRP and IL-6 (
Identifiants
pubmed: 33920422
pii: cancers13081824
doi: 10.3390/cancers13081824
pmc: PMC8069748
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Lung Cancer. 2017 Jul;109:68-73
pubmed: 28577953
Eur J Cancer. 2017 Nov;86:394-402
pubmed: 29100194
Ann Surg Oncol. 2014 Mar;21(3):891-8
pubmed: 24254205
BMC Geriatr. 2013 Jun 21;13:64
pubmed: 23786540
J Geriatr Oncol. 2016 Nov;7(6):479-491
pubmed: 27338516
Vet J. 2015 Aug;205(2):161-74
pubmed: 25981934
Eur J Surg Oncol. 2015 Jul;41(7):844-51
pubmed: 25935371
Esophagus. 2020 Jul;17(3):279-288
pubmed: 31845119
Mech Ageing Dev. 2007 Jan;128(1):92-105
pubmed: 17116321
Biomarkers. 2011 Aug 19;16(6):530-535
pubmed: 21854219
Cancer Metastasis Rev. 2010 Jun;29(2):273-83
pubmed: 20390322
J Surg Oncol. 2018 Jun;117(8):1672-1678
pubmed: 29723410
Eur J Cancer Care (Engl). 2020 Jan;29(1):e13170
pubmed: 31571340
FEBS Lett. 2005 Apr 11;579(10):2035-9
pubmed: 15811314
Eur J Surg Oncol. 2019 Aug;45(8):1403-1409
pubmed: 31104780
J Emerg Med. 1999 Nov-Dec;17(6):1019-25
pubmed: 10595891
Clin Mol Allergy. 2017 Dec 14;15:21
pubmed: 29259496
Arch Immunol Ther Exp (Warsz). 2016 Apr;64(2):111-26
pubmed: 26658771
Exp Mol Pathol. 2006 Jun;80(3):219-27
pubmed: 16460728
Ann Surg Oncol. 2018 Jan;25(1):231-238
pubmed: 29058145
Ann N Y Acad Sci. 1982;389:406-18
pubmed: 6953917
J Geriatr Oncol. 2020 Jun;11(5):873-879
pubmed: 32035801
Biomolecules. 2019 Jun 07;9(6):
pubmed: 31181700
Nephrol Dial Transplant. 2004 May;19(5):1154-60
pubmed: 14993508
Rep Pract Oncol Radiother. 2013 Jul 26;18(5):304-9
pubmed: 24416568
Surgery. 2000 Feb;127(2):117-26
pubmed: 10686974
Mech Ageing Dev. 2007 Jan;128(1):83-91
pubmed: 17118425
J Am Geriatr Soc. 2008 Dec;56(12):2340-8
pubmed: 19093934
J Gerontol A Biol Sci Med Sci. 2012 Jun;67(6):671-6
pubmed: 22389462
Anticancer Res. 2009 Dec;29(12):5005-12
pubmed: 20044609
Front Immunol. 2018 Apr 13;9:754
pubmed: 29706967
J Surg Oncol. 2020 Mar;121(4):676-687
pubmed: 31930514
Acta Oncol. 2013 Nov;52(8):1691-8
pubmed: 24102179
Cancer Treat Rev. 2013 Aug;39(5):534-40
pubmed: 22995477
Clin J Am Soc Nephrol. 2016 Sep 7;11(9):1546-56
pubmed: 27340285
Lab Anim Res. 2018 Jun;34(2):80-83
pubmed: 29937915
Acta Oncol. 2016;55 Suppl 1:1-6
pubmed: 26781233
APMIS. 2014 Dec;122(12):1223-9
pubmed: 24909386
J Immunopharmacol. 1986;8(1):89-97
pubmed: 3711675