Thymoquinone, a Dietary Bioactive Compound, Exerts Anti-Inflammatory Effects in Colitis by Stimulating Expression of the Colonic Epithelial PPAR-γ Transcription Factor.
Animals
Anti-Inflammatory Agents
/ pharmacology
Benzoquinones
/ pharmacology
Colitis
/ chemically induced
Colon
/ drug effects
Dextran Sulfate
Disease Models, Animal
Mice
Mice, Inbred C57BL
Mitogen-Activated Protein Kinases
/ metabolism
NF-kappa B
/ metabolism
PPAR gamma
/ metabolism
Phytochemicals
/ pharmacology
Signal Transduction
/ drug effects
Transcription Factors
/ metabolism
DSS colitis
MAPK and colitis
PPAR-γ expression
PPAR-γ promoter
Thymoquinone
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
17 Apr 2021
17 Apr 2021
Historique:
received:
17
02
2021
revised:
07
04
2021
accepted:
15
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
27
5
2021
Statut:
epublish
Résumé
Inflammatory bowel diseases (IBD) are chronic inflammatory disorders with increasing incidence and prevalence worldwide. Here, we investigated thymoquinone (TQ), a naturally occurring phytochemical present in
Identifiants
pubmed: 33920708
pii: nu13041343
doi: 10.3390/nu13041343
pmc: PMC8073634
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Benzoquinones
0
NF-kappa B
0
PPAR gamma
0
Phytochemicals
0
Transcription Factors
0
Dextran Sulfate
9042-14-2
Mitogen-Activated Protein Kinases
EC 2.7.11.24
thymoquinone
O60IE26NUF
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : United Arab Emirates University
ID : 31M384 and 31R230
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