Computational Design and Development of Benzodioxane-Benzamides as Potent Inhibitors of FtsZ by Exploring the Hydrophobic Subpocket.

Bacillus subtilis FtsZ FtsZ inhibition MIC MRSA MSSA Z ring antibiotic-resistance gram positive-dependent diseases

Journal

Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404

Informations de publication

Date de publication:
15 Apr 2021
Historique:
received: 13 03 2021
revised: 09 04 2021
accepted: 13 04 2021
entrez: 30 4 2021
pubmed: 1 5 2021
medline: 1 5 2021
Statut: epublish

Résumé

Multidrug resistant

Identifiants

pubmed: 33920895
pii: antibiotics10040442
doi: 10.3390/antibiotics10040442
pmc: PMC8071314
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM131705
Pays : United States
Organisme : NIH HHS
ID : GM131705
Pays : United States

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Auteurs

Valentina Straniero (V)

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Luigi Mangiagalli, 25, 20133 Milano, Italy.

Victor Sebastián-Pérez (V)

Centro de Investigaciones Biológicas (CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.
Exscientia, The Schrödinger Building, Oxford Science Park, Oxford OX4 4GE, UK.

Lorenzo Suigo (L)

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Luigi Mangiagalli, 25, 20133 Milano, Italy.

William Margolin (W)

Department of Microbiology and Molecular Genetics, McGovern Medical School, University of Texas, Houston, TX 77030, USA.

Andrea Casiraghi (A)

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Luigi Mangiagalli, 25, 20133 Milano, Italy.

Martina Hrast (M)

Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta, 7, 1000 Ljubljana, Slovenia.

Carlo Zanotto (C)

Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Via Vanvitelli, 32, 20129 Milano, Italy.

Irena Zdovc (I)

Veterinary Faculty, University of Ljubljana, Gerbičeva, 60, 1000 Ljubljana, Slovenia.

Antonia Radaelli (A)

Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Via Vanvitelli, 32, 20129 Milano, Italy.

Ermanno Valoti (E)

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Luigi Mangiagalli, 25, 20133 Milano, Italy.

Classifications MeSH