Targeting Post-Translational Modifications of the p73 Protein: A Promising Therapeutic Strategy for Tumors.
acetylation
cancer therapy
p73
phosphorylation
post-translational modification
ubiquitin
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
15 Apr 2021
15 Apr 2021
Historique:
received:
16
03
2021
revised:
12
04
2021
accepted:
12
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
The tumor suppressor p73 is a member of the p53 family and is expressed as different isoforms with opposing properties. The TAp73 isoforms act as tumor suppressors and have pro-apoptotic effects, whereas the ΔNp73 isoforms lack the N-terminus transactivation domain and behave as oncogenes. The TAp73 protein has a high degree of similarity with both p53 function and structure, and it induces the regulation of various genes involved in the cell cycle and apoptosis. Unlike those of the
Identifiants
pubmed: 33921128
pii: cancers13081916
doi: 10.3390/cancers13081916
pmc: PMC8071514
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Umm Al-Qura University
ID : 19-MED-1-02-0008
Références
Cell Death Dis. 2012 Mar 15;3:e285
pubmed: 22419114
Neoplasia. 2014 Oct 23;16(10):789-800
pubmed: 25379016
Cell Cycle. 2008 May 1;7(9):1231-7
pubmed: 18418053
Oncogene. 2016 Jan 28;35(4):513-27
pubmed: 25893286
Nature. 1999 Jun 24;399(6738):814-7
pubmed: 10391251
Cancer Res. 2002 Feb 1;62(3):636-41
pubmed: 11830511
BMB Rep. 2015 Feb;48(2):81-90
pubmed: 25441426
Cell Mol Life Sci. 2009 Jun;66(11-12):1858-67
pubmed: 19387548
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3142-7
pubmed: 19218448
Semin Cancer Biol. 2017 Apr;43:42-48
pubmed: 28077309
J Oncol. 2020 Jan 13;2020:7131802
pubmed: 32411240
J Biol Chem. 2008 Mar 28;283(13):8555-63
pubmed: 18174154
Oncogene. 2007 Aug 9;26(36):5169-83
pubmed: 17334395
Cell Signal. 2011 Jan;23(1):152-60
pubmed: 20807569
Oncogene. 2005 Nov 3;24(48):7156-69
pubmed: 16170377
Oncogene. 2009 Sep 3;28(35):3157-66
pubmed: 19581926
Cancers (Basel). 2019 Dec 24;12(1):
pubmed: 31878315
PLoS One. 2010 Aug 12;5(8):e12124
pubmed: 20711342
Cancer Cell Int. 2019 Aug 22;19:216
pubmed: 31440117
Mol Cell Biol. 2004 Dec;24(24):10593-610
pubmed: 15572666
Cell Death Differ. 2011 Dec;18(12):1865-75
pubmed: 21597459
Mutat Res. 2011 Jan 10;706(1-2):28-35
pubmed: 21040738
Blood. 2009 Apr 16;113(16):3744-53
pubmed: 19096009
PLoS One. 2020 Jun 12;15(6):e0234468
pubmed: 32530958
Nat Cell Biol. 2004 Oct;6(10):1003-9
pubmed: 15448697
J Biol Chem. 2005 Apr 29;280(17):16665-75
pubmed: 15723830
Mol Cancer Res. 2004 Jul;2(7):371-86
pubmed: 15280445
Biochim Biophys Acta Gen Subj. 2019 Apr;1863(4):760-770
pubmed: 30735716
Int J Biochem Cell Biol. 2001 Oct;33(10):935-9
pubmed: 11470228
Mol Cancer Res. 2011 Dec;9(12):1780-90
pubmed: 21994467
Environ Toxicol. 2017 Feb;32(2):669-678
pubmed: 27060453
Exp Cell Res. 2006 Oct 15;312(17):3370-8
pubmed: 16934800
J Cancer Res Clin Oncol. 2018 Aug;144(8):1509-1521
pubmed: 29728763
Cancer Cell. 2012 Feb 14;21(2):196-211
pubmed: 22340593
Cancer Sci. 2005 Nov;96(11):729-37
pubmed: 16271066
FEBS Lett. 2011 Jan 3;585(1):255-60
pubmed: 21146529
Nat Cell Biol. 2011 Jun;13(6):728-33
pubmed: 21532586
J Agric Food Chem. 2015 Feb 11;63(5):1540-6
pubmed: 25611974
Mol Cell. 2004 Jun 4;14(5):625-36
pubmed: 15175157
Cancer Res. 2008 Jul 15;68(14):5572-80
pubmed: 18632609
Oncogene. 2001 Feb 8;20(6):748-58
pubmed: 11314008
J Natl Cancer Inst. 2015 Jun 01;107(6):djv165
pubmed: 26032612
Cell Cycle. 2010 Nov 15;9(22):4584-91
pubmed: 21088494
Int J Mol Sci. 2020 May 30;21(11):
pubmed: 32486158
Life Sci. 2018 May 1;200:26-30
pubmed: 29534993
Mol Med. 1995 Sep;1(6):659-66
pubmed: 8529132
Annu Rev Biochem. 2012;81:203-29
pubmed: 22524316
Future Sci OA. 2019 Jan 18;5(2):FSO366
pubmed: 30820346
Blood. 2004 Jul 15;104(2):519-25
pubmed: 15031205
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820947489
pubmed: 32912061
Carcinogenesis. 2004 Feb;25(2):157-67
pubmed: 14578165
Cell. 2001 Oct 19;107(2):149-59
pubmed: 11672523
Cell Death Differ. 2005 Dec;12(12):1564-77
pubmed: 16195739
Biochem J. 2007 Aug 1;405(3):617-23
pubmed: 17521288
Nat Struct Mol Biol. 2008 Dec;15(12):1334-42
pubmed: 19043414
Drug Saf. 2009;32(12):1109-22
pubmed: 19916578
Cell. 2001 Oct 19;107(2):137-48
pubmed: 11672522
Cell Immunol. 2010;263(2):235-40
pubmed: 20471636
Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11280-5
pubmed: 17592138
Cells. 2019 Jun 15;8(6):
pubmed: 31208103
Oncogene. 2013 Sep 26;32(39):4721-6
pubmed: 23085759
Anticancer Drugs. 2004 Apr;15(4):389-99
pubmed: 15057144
J Biol Chem. 2007 Jan 26;282(4):2466-72
pubmed: 17135250
Biochem Pharmacol. 2010 May 1;79(9):1251-60
pubmed: 20026309
Biochem Biophys Res Commun. 2005 Jun 10;331(3):707-12
pubmed: 15865926
Cancer Res. 2004 Nov 15;64(22):8152-5
pubmed: 15548678
Cancer Cell. 2002 Apr;1(3):289-98
pubmed: 12086865
Oncogene. 2002 Jan 31;21(6):974-9
pubmed: 11840343
Cancer Res. 1994 Sep 15;54(18):4855-78
pubmed: 8069852
Invest New Drugs. 2012 Oct;30(5):1813-9
pubmed: 21881916
Mol Cell Biol. 2014 Oct 1;34(19):3754-64
pubmed: 25071155
Cell Mol Life Sci. 2007 Aug;64(15):1979-96
pubmed: 17530464
Biochem Biophys Res Commun. 2010 Dec 17;403(3-4):405-11
pubmed: 21093410
J Biol Chem. 2008 Oct 10;283(41):27462-27468
pubmed: 18701449
Curr Opin Investig Drugs. 2002 Nov;3(11):1672-8
pubmed: 12476972
Cell Cycle. 2013 Sep 1;12(17):2733-7
pubmed: 23966173
J Exp Med. 2002 Sep 16;196(6):765-80
pubmed: 12235210
Cancer Med. 2016 Jan;5(1):74-87
pubmed: 26625870
Apoptosis. 2010 Feb;15(2):183-95
pubmed: 19882352
Cell Death Differ. 2001 Dec;8(12):1213-23
pubmed: 11753569
Stem Cells Int. 2016;2016:6705927
pubmed: 26880980
Eur J Surg Oncol. 2013 Jan;39(1):100-6
pubmed: 23102595
Nature. 2006 Oct 5;443(7111):590-3
pubmed: 16964240
Mol Cell Biol. 2000 Feb;20(4):1299-310
pubmed: 10648616
Nature. 1999 Jun 24;399(6738):806-9
pubmed: 10391249
Curr Pharm Des. 2017;23(1):95-107
pubmed: 27719640
J Am Soc Nephrol. 2006 Jul;17(7):1807-19
pubmed: 16738015
J Pathol. 2006 Dec;210(4):385-9
pubmed: 17044134
Drug Resist Updat. 2006 Dec;9(6):288-306
pubmed: 17287142
Clin Cancer Res. 2010 Apr 15;16(8):2295-307
pubmed: 20371694
Cell. 1997 Aug 22;90(4):809-19
pubmed: 9288759
Mol Cell. 2002 Jan;9(1):175-86
pubmed: 11804596
J Biol Chem. 2011 Oct 14;286(41):35388-35395
pubmed: 21852228
Nature. 1999 Jun 24;399(6738):809-13
pubmed: 10391250
Nat Cell Biol. 2006 Nov;8(11):1277-83
pubmed: 17041588
J Biol Chem. 2010 Jul 16;285(29):22473-83
pubmed: 20404322
Nat Genet. 2004 Jan;36(1):55-62
pubmed: 14702041
Cell Death Discov. 2020 Jul 3;6:55
pubmed: 32655893
Oncotarget. 2015 Aug 28;6(25):21479-92
pubmed: 26025930
Epigenetics. 2009 Oct 1;4(7):445-51
pubmed: 19838051
Biochem Biophys Res Commun. 2015 Nov 13;467(2):316-21
pubmed: 26435500
Int J Mol Sci. 2019 Dec 11;20(24):
pubmed: 31835684
J Zhejiang Univ Sci B. 2020 Sept.;21(9):745-748
pubmed: 32893531
Cancer Res. 2003 Jun 15;63(12):3418-24
pubmed: 12810679
J Vis Exp. 2019 Jul 25;(149):
pubmed: 31403616
Oncogene. 1997 Sep;15(11):1363-7
pubmed: 9315105
Cell Death Dis. 2013 Jul 04;4:e704
pubmed: 23828567
J Biosci. 2017 Dec;42(4):547-554
pubmed: 29229873
IARC Sci Publ. 2004;(157):247-70
pubmed: 15055300
Food Funct. 2014 Dec;5(12):3320-8
pubmed: 25371988
Mol Cell. 2005 May 13;18(4):447-59
pubmed: 15893728
FEBS Lett. 2012 May 21;586(10):1397-402
pubmed: 22673504
Oncotarget. 2016 Jan 12;7(2):1477-85
pubmed: 26621835
J Dermatolog Treat. 2003;14 Suppl 3:15-22
pubmed: 14522637
Cold Spring Harb Perspect Biol. 2010 Jan;2(1):a001008
pubmed: 20182602
Cell Death Differ. 2014 Oct;21(10):1535-45
pubmed: 24992930
Genes Cells. 2009 Jul;14(7):775-88
pubmed: 19490146
Lipids Health Dis. 2011 Dec 16;10:236
pubmed: 22177381
Cell Death Discov. 2019 Mar 11;5:77
pubmed: 30886745
Clin Cancer Res. 2009 Nov 1;15(21):6495-502
pubmed: 19861456
Cell. 1993 Nov 19;75(4):817-25
pubmed: 8242752
Prescrire Int. 2016 Nov;25(176):257-259
pubmed: 30715819
BMC Complement Altern Med. 2012 Nov 15;12:220
pubmed: 23153283
J Biol Chem. 2001 Jan 5;276(1):48-52
pubmed: 11076933
J Biol Chem. 2002 Sep 13;277(37):33758-65
pubmed: 12097319
Cancer Metastasis Rev. 2010 Dec;29(4):613-39
pubmed: 20922462
EMBO J. 2005 Feb 23;24(4):836-48
pubmed: 15678106
Nat Med. 2011 Mar;17(3):347-55
pubmed: 21317885
Cell Death Differ. 2020 Feb;27(2):758-772
pubmed: 31285543
Cell Death Differ. 2007 Apr;14(4):743-51
pubmed: 17110958
Trends Cancer. 2019 Oct;5(10):632-653
pubmed: 31706510
Cell Cycle. 2011 Jun 15;10(12):1912-5
pubmed: 21558803
J Biol Chem. 2003 Jul 25;278(30):27421-31
pubmed: 12676926
Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12877-82
pubmed: 20615966
Blood. 1999 Aug 1;94(3):1113-20
pubmed: 10419905
Nucleic Acids Res. 2014 Jul;42(13):8310-9
pubmed: 24981513
EMBO Rep. 2018 Nov;19(11):
pubmed: 30213795
Genes Cells. 2002 Nov;7(11):1173-82
pubmed: 12390251
J Biol Chem. 2004 Dec 10;279(50):52175-82
pubmed: 15469940
FEBS Lett. 2001 Feb 16;490(3):202-8
pubmed: 11223036
Nat Genet. 1998 Oct;20(2):189-93
pubmed: 9771714
Leukemia. 2006 May;20(5):757-66
pubmed: 16541141
Med Res Rev. 2016 Nov;36(6):1036-1079
pubmed: 27406026
Eur Biophys J. 2014 May;43(4-5):199-206
pubmed: 24687685
Oncogene. 1999 Mar 25;18(12):2101-6
pubmed: 10321734
Science. 2004 Feb 13;303(5660):1010-4
pubmed: 14963330
Mol Cell. 1998 Sep;2(3):305-16
pubmed: 9774969
Cell. 1993 Nov 19;75(4):805-16
pubmed: 8242751
Oncol Ther. 2016;4(1):73-89
pubmed: 28261641
J Cell Physiol. 2007 Jan;210(1):161-6
pubmed: 16998810
Mol Cell Biol. 1999 May;19(5):3257-66
pubmed: 10207051
Leuk Res. 2001 Jun;25(6):441-7
pubmed: 11337015
Dig Dis Sci. 2018 Jan;63(1):126-134
pubmed: 29197940
Curr Cancer Drug Targets. 2018;18(8):720-736
pubmed: 28669336
Ann N Y Acad Sci. 2000;926:90-100
pubmed: 11193045
Pharmacol Res. 2020 Dec;162:105245
pubmed: 33069756
Oncogene. 1999 Jul 8;18(27):3923-9
pubmed: 10435614
Aging (Albany NY). 2012 Mar;4(3):202-5
pubmed: 22388545
Mol Cell Biol. 2002 Jul;22(14):5222-34
pubmed: 12077349
Mol Cancer Res. 2019 Jan;17(1):153-164
pubmed: 30131448
Cell Div. 2018 Dec 26;13:10
pubmed: 30603043
Oncotarget. 2018 Jun 19;9(47):28599-28611
pubmed: 29983883
Anticancer Res. 2017 Jan;37(1):191-196
pubmed: 28011490
Biochem J. 2002 Feb 1;361(Pt 3):587-95
pubmed: 11802788
Mol Cell. 2001 Sep;8(3):713-8
pubmed: 11583632
Cancer Cell. 2008 Jul 8;14(1):10-21
pubmed: 18598940
Mol Cancer Ther. 2008 Sep;7(9):3047-55
pubmed: 18790784