Fully Automated Synthesis of Novel TSPO PET Imaging Ligand [
benzodiazepine
molecular imaging
neuroinflammation
positron emission tomography probe
translocator protein
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
19 Apr 2021
19 Apr 2021
Historique:
received:
17
03
2021
revised:
15
04
2021
accepted:
16
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
25
5
2021
Statut:
epublish
Résumé
Benzodiazepines, including temazepam are described as TSPO antagonists. In fact, TSPO was initially described as a peripheral benzodiazepine receptor (PBR) with a secondary binding site for diazepam. TSPO is a potential imaging target of neuroinflammation because there is an amplification of the expression of this receptor. Herein, we developed a novel fluorinated benzodiazepine ligand, [ [ We obtained 2.0-3.0% decay-uncorrected radiochemical activity yield (3.7% decay-corrected) within the whole synthesis time about 33 min. The radiochemical purity of [ This automated procedure may be used as basis for future production of [
Identifiants
pubmed: 33921765
pii: molecules26082372
doi: 10.3390/molecules26082372
pmc: PMC8073130
pii:
doi:
Substances chimiques
Fluorine Radioisotopes
0
Radiopharmaceuticals
0
Benzodiazepines
12794-10-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero dello Sviluppo Economico
ID : B68I17001000008
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