Plasminogen Activators in Neurovascular and Neurodegenerative Disorders.
neurodegeneration
tissue-type plasminogen activator (tPA)
urokinase-type plasminogen activator (uPA)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Apr 2021
22 Apr 2021
Historique:
received:
18
03
2021
revised:
14
04
2021
accepted:
20
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
15
5
2021
Statut:
epublish
Résumé
The neurovascular unit (NVU) is a dynamic structure assembled by endothelial cells surrounded by a basement membrane, pericytes, astrocytes, microglia and neurons. A carefully coordinated interplay between these cellular and non-cellular components is required to maintain normal neuronal function, and in line with these observations, a growing body of evidence has linked NVU dysfunction to neurodegeneration. Plasminogen activators catalyze the conversion of the zymogen plasminogen into the two-chain protease plasmin, which in turn triggers a plethora of physiological events including wound healing, angiogenesis, cell migration and inflammation. The last four decades of research have revealed that the two mammalian plasminogen activators, tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), are pivotal regulators of NVU function during physiological and pathological conditions. Here, we will review the most relevant data on their expression and function in the NVU and their role in neurovascular and neurodegenerative disorders.
Identifiants
pubmed: 33922229
pii: ijms22094380
doi: 10.3390/ijms22094380
pmc: PMC8122722
pii:
doi:
Substances chimiques
Receptors, Urokinase Plasminogen Activator
0
Plasminogen Activators
EC 3.4.21.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NIH HHS
ID : NS091201
Pays : United States
Organisme : U.S. Department of Veterans Affairs
ID : I01BX003441
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