Inhibition of Glycolysis Suppresses Cell Proliferation and Tumor Progression In Vivo: Perspectives for Chronotherapy.
Animals
Apoptosis
Cell Proliferation
Chronotherapy
/ methods
Colonic Neoplasms
/ drug therapy
Glucose
/ metabolism
Glycolysis
Humans
Male
Mice
Mice, Nude
Phosphofructokinase-2
/ antagonists & inhibitors
Pyridines
/ pharmacology
Quinolines
/ pharmacology
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
DLD1 cells
HUVEC
PFK15
PFKFB3
cancer
chronotherapy
glycolysis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Apr 2021
22 Apr 2021
Historique:
received:
23
03
2021
revised:
16
04
2021
accepted:
20
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
15
5
2021
Statut:
epublish
Résumé
A high rate of glycolysis is considered a hallmark of tumor progression and is caused by overexpression of the enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3). Therefore, we analyzed the possibility of inhibiting tumor and endothelial cell metabolism through the inhibition of PFKFB3 by a small molecule, (
Identifiants
pubmed: 33922320
pii: ijms22094390
doi: 10.3390/ijms22094390
pmc: PMC8122821
pii:
doi:
Substances chimiques
PFK15
0
Pyridines
0
Quinolines
0
PFKFB3 protein, human
EC 2.7.1.105
Phosphofructokinase-2
EC 2.7.1.105
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Slovak Research and Development Agency
ID : APVV-17-0178
Organisme : Slovak Research and Development Agency
ID : APVV-16-0209
Organisme : Research and Development Operational Programme funded by the ERDF
ID : ITMS 26240220086
Organisme : Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic
ID : VEGA 2/0050/19
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