Histological and Immunohistochemical Characterization of Vomeronasal Organ Aging in Mice.
aging
chemoreception
histology
pathology
vomeronasal organ
Journal
Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614
Informations de publication
Date de publication:
22 Apr 2021
22 Apr 2021
Historique:
received:
03
03
2021
revised:
20
04
2021
accepted:
21
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
The vomeronasal organ (VNO) plays a crucial role in animal behavior since it is responsible for semiochemical detection and, thus, for intra- and interspecific chemical communication, through the vomeronasal sensory epithelium (VNSE), composed of bipolar sensory neurons. This study aimed to explore a well-recognized cause of neuronal degeneration, only rarely explored in this organ: aging. Murine VNOs were evaluated according to 3 age groups (3, 10, and 24 months) by histology to assess VNSE changes such as cellular degeneration or glycogen accumulation and by immunohistochemistry to explore nervous configuration, proliferation capability, and apoptosis with the expression of olfactory marker protein (OMP), Gαi2, Gαo, Ki-67, and cleaved caspase-3 proteins. These markers were quantified as percentages of positive signal in the VNSE and statistical analyses were performed. Cellular degeneration increased with age (
Identifiants
pubmed: 33922332
pii: ani11051211
doi: 10.3390/ani11051211
pmc: PMC8146790
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Curr Biol. 2003 Jul 15;13(14):1214-9
pubmed: 12867032
J Neurosci Res. 2005 Jan 1-15;79(1-2):74-80
pubmed: 15578727
Front Neuroanat. 2009 Oct 30;3:22
pubmed: 19949452
Prog Neurobiol. 2003 Jun;70(3):245-318
pubmed: 12951145
J Anat. 1984 Jun;138 ( Pt 4):771-87
pubmed: 6746408
Trends Neurosci. 2006 Jan;29(1):1-7
pubmed: 16271402
J Feline Med Surg. 2016 Dec;18(12):997-1002
pubmed: 26404027
Ageing Res Rev. 2016 May;27:42-55
pubmed: 26970374
Brain Res. 1980 Mar 3;185(1):103-13
pubmed: 7353170
Behav Neurosci. 2006 Aug;120(4):925-36
pubmed: 16893298
Microsc Res Tech. 2002 Aug 1;58(3):251-60
pubmed: 12203702
Brain Res Brain Res Rev. 1999 Apr;29(2-3):265-95
pubmed: 10209236
Vet Med Int. 2010 Aug 29;2010:
pubmed: 20871868
Front Psychol. 2014 Feb 07;5:20
pubmed: 24570664
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2010 Oct;196(10):685-700
pubmed: 20680632
Anat Histol Embryol. 1997 Sep;26(3):179-86
pubmed: 9334496
J Neurosci. 2010 Nov 17;30(46):15686-94
pubmed: 21084624
Nature. 2011 Sep 21;478(7368):241-5
pubmed: 21937988
Front Neuroanat. 2014 Jul 14;8:63
pubmed: 25071468
Biol Reprod. 2000 Sep;63(3):953-8
pubmed: 10952943
Cell. 2011 Mar 4;144(5):810-23
pubmed: 21376239
Cell. 1995 Oct 20;83(2):195-206
pubmed: 7585937
J Neurosci. 2011 Feb 23;31(8):2974-82
pubmed: 21414919
Exp Gerontol. 2010 Oct;45(10):772-8
pubmed: 20117203
Nature. 2009 May 28;459(7246):574-7
pubmed: 19387439
Front Cell Neurosci. 2020 Feb 11;14:16
pubmed: 32116562
Chem Senses. 2007 Jan;32(1):57-64
pubmed: 17071943
Physiol Rev. 2005 Oct;85(4):1159-204
pubmed: 16183910
Front Neurosci. 2014 Jun 26;8:182
pubmed: 25018692
Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12898-903
pubmed: 21768373
Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5135-5143
pubmed: 30804203
J Neurosci. 2016 Mar 9;36(10):2995-3006
pubmed: 26961953
Cell. 1997 Aug 22;90(4):763-73
pubmed: 9288755
J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):16-29
pubmed: 26786204
Ageing Res Rev. 2004 Apr;3(2):215-32
pubmed: 15177056
Mol Aspects Med. 2015 Dec;46:70-7
pubmed: 26344371
Sci Rep. 2017 Feb 03;7:41807
pubmed: 28155917
Int J Mol Sci. 2018 Nov 12;19(11):
pubmed: 30424529
J Steroid Biochem Mol Biol. 1991 Oct;39(4B):661-9
pubmed: 1892795
Cell. 2003 Mar 7;112(5):607-18
pubmed: 12628182