Low P66shc with High SerpinB3 Levels Favors Necroptosis and Better Survival in Hepatocellular Carcinoma.
animal experimental models
liver cancer
oxidative stress
prognosis
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
23 Apr 2021
23 Apr 2021
Historique:
received:
15
03
2021
revised:
13
04
2021
accepted:
16
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Cell proliferation and escape from apoptosis are important pathological features of hepatocellular carcinoma (HCC), one of the tumors with the highest mortality rate worldwide. The aim of the study was to evaluate the expression of the pro-apoptotic p66shc and the anti-apoptotic SerpinB3 in HCCs in relation to clinical outcome, cell fate and tumor growth. p66shc and SerpinB3 were evaluated in 67 HCC specimens and the results were correlated with overall survival. Proliferation and cell death markers were analyzed in hepatoma cells overexpressing SerpinB3, under different stress conditions.
Identifiants
pubmed: 33922660
pii: biology10050363
doi: 10.3390/biology10050363
pmc: PMC8145214
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Ministry Education University and Research
ID : RBLA03S4SP_005
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