Gene Expression Profiling of Pancreas Neuroendocrine Tumors with Different Ki67-Based Grades.
Ki67
LINE-1
NET
gene expression profiling
grade
neuroendocrine tumor
pancreas
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
23 Apr 2021
23 Apr 2021
Historique:
received:
16
03
2021
revised:
16
04
2021
accepted:
20
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Pancreatic neuroendocrine tumors (PanNETs) display variable aggressive behavior. A major predictor of survival is tumor grade based on the Ki67 proliferation index. As information on transcriptomic profiles of PanNETs with different tumor grades is limited, we investigated 29 PanNETs (17 G1, 7 G2, 5 G3) for their expression profiles, mutations in 16 PanNET relevant genes and LINE-1 DNA methylation profiles. A total of 3050 genes were differentially expressed between tumors with different grades (
Identifiants
pubmed: 33922803
pii: cancers13092054
doi: 10.3390/cancers13092054
pmc: PMC8122987
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : European Community ERANET PMTR-pNET
ID : cod. D18TR5, B46C17000260001
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 5x1000 n.12182; IG 2003 14696
Organisme : Università Cattolica internal grant
ID : line D.1 2017-R4124500591
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