Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities.
anticancer
cancer therapy
hormonal therapy
phytomelatonin
pineal gland
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
25 Apr 2021
25 Apr 2021
Historique:
received:
26
02
2021
revised:
13
04
2021
accepted:
19
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
18
5
2021
Statut:
epublish
Résumé
Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and experimental studies have documented that melatonin could inhibit different types of cancer in vitro and in vivo. Results showed the involvement of melatonin in different anticancer mechanisms including apoptosis induction, cell proliferation inhibition, reduction in tumor growth and metastases, reduction in the side effects associated with chemotherapy and radiotherapy, decreasing drug resistance in cancer therapy, and augmentation of the therapeutic effects of conventional anticancer therapies. Clinical trials revealed that melatonin is an effective adjuvant drug to all conventional therapies. This review summarized melatonin biosynthesis, availability from natural sources, metabolism, bioavailability, anticancer mechanisms of melatonin, its use in clinical trials, and pharmaceutical formulation. Studies discussed in this review will provide a solid foundation for researchers and physicians to design and develop new therapies to treat and prevent cancer using melatonin.
Identifiants
pubmed: 33923028
pii: molecules26092506
doi: 10.3390/molecules26092506
pmc: PMC8123278
pii:
doi:
Substances chimiques
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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