Extracorporeal Membrane Oxygenation-Induced Hemolysis: An In Vitro Study to Appraise Causative Factors.
anticoagulants
blood donor gender
blood trauma
flow rate
in vitro model
mechanical circulatory device
Journal
Membranes
ISSN: 2077-0375
Titre abrégé: Membranes (Basel)
Pays: Switzerland
ID NLM: 101577807
Informations de publication
Date de publication:
25 04 2021
25 04 2021
Historique:
received:
19
03
2021
revised:
19
04
2021
accepted:
21
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
In vitro hemolysis testing is commonly used to determine hemocompatibility of ExtraCorporeal Membrane Oxygenation (ECMO). However, poor reproducibility remains a challenging problem, due to several unidentified influencing factors. The present study investigated potential factors, such as flow rates, the use of anticoagulants, and gender of blood donors, which could play a role in hemolysis. Fresh human whole blood was anticoagulated with either citrate (n = 6) or heparin (n = 12; 6 female and 6 male blood donors). Blood was then circulated for 360 min at 4 L/min or 1.5 L/min. Regardless of flow rate conditions, hemolysis remained unchanged over time in citrated blood, but significantly increased after 240 min circulation in heparinized blood (
Identifiants
pubmed: 33923070
pii: membranes11050313
doi: 10.3390/membranes11050313
pmc: PMC8145168
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Health and Medical Research Council Centre for Research Excellence in Advanced Cardio-respiratory Therapies Improving Organ Support
ID : APP1079421
Organisme : The Prince Charles Hospital Foundation Research Fellowships
ID : RF2019-02
Organisme : The Prince Charles Hospital Foundation Team Grant
ID : TM2017-04
Références
J Clin Med. 2020 Apr 02;9(4):
pubmed: 32252267
Sci Rep. 2018 Jul 5;8(1):10225
pubmed: 29977064
Intensive Care Med Exp. 2019 Aug 20;7(1):51
pubmed: 31432279
Artif Organs. 2013 Sep;37(9):793-801
pubmed: 23981196
Artif Organs. 2015 Sep;39(9):795-802
pubmed: 25899978
Biorheology. 2016 Nov 9;53(3-4):137-149
pubmed: 27662271
ASAIO J. 2020 Mar;66(3):332-338
pubmed: 31045918
Perfusion. 2020 May;35(1_suppl):38-49
pubmed: 32397884
Blood Transfus. 2021 Mar;19(2):124-134
pubmed: 33370227
Artif Organs. 2012 Aug;36(8):724-30
pubmed: 22882442
ASAIO J. 2002 Nov-Dec;48(6):636-9
pubmed: 12455774
Artif Organs. 2015 Feb;39(2):93-101
pubmed: 25066768
J Thorac Dis. 2015 Jul;7(7):E166-76
pubmed: 26380745
Front Physiol. 2016 Jul 15;7:288
pubmed: 27471472
Artif Organs. 2003 Jun;27(6):517-29
pubmed: 12780506
Artif Organs. 1997 Jul;21(7):704-9
pubmed: 9212943
Artif Organs. 1994 Jan;18(1):7-10
pubmed: 8141660
J Perinatol. 2007 Jun;27(6):380-4
pubmed: 17443201
ASAIO J. 2020 Jun;66(6):637-644
pubmed: 31335374
Blood Adv. 2017 Jun 27;1(15):1132-1141
pubmed: 29034365
Artif Organs. 2020 Jul;44(7):717-726
pubmed: 31970795
Artif Organs. 2017 Oct;41(10):934-947
pubmed: 28744884
ASAIO J. 2014 Jul-Aug;60(4):413-8
pubmed: 24727536
ASAIO J. 2015 Mar-Apr;61(2):190-5
pubmed: 25419829
Scand J Clin Lab Invest. 1959;11:66-70
pubmed: 13646603
Biomol Ther (Seoul). 2017 Sep 1;25(5):461-470
pubmed: 28365976
PLoS One. 2015 Apr 22;10(4):e0124034
pubmed: 25902047
ASAIO J. 2021 Jun 1;67(6):632-641
pubmed: 32947284
Biorheology. 2016;53(5-6):237-249
pubmed: 28222499
Clin Hemorheol Microcirc. 1998 Apr;18(1):67-74
pubmed: 9653588
PLoS One. 2020 Jan 27;15(1):e0227793
pubmed: 31986168
Artif Organs. 2013 Oct;37(10):894-903
pubmed: 23738621
J Transl Med. 2021 Jan 5;19(1):2
pubmed: 33402176
Crit Care. 2019 Nov 6;23(1):348
pubmed: 31694688
ASAIO J. 2021 Mar 1;67(3):270-275
pubmed: 33627600
Ann Cardiothorac Surg. 2019 Jan;8(1):E1-E8
pubmed: 30854330