Anti-Inflammatory Role of Netrin-4 in Diabetic Retinopathy.
chronic inflammation
diabetic retinopathy
in vivo
netrin-4
retina
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Apr 2021
25 Apr 2021
Historique:
received:
27
03
2021
revised:
21
04
2021
accepted:
23
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
29
5
2021
Statut:
epublish
Résumé
Diabetic retinopathy is characterized by dysfunction of the retinal vascular network, combined with a persistent low-grade inflammation that leads to vision-threatening complications. Netrin-4 (NTN4) is a laminin-related secreted protein and guidance cue molecule present in the vascular basal membrane and highly expressed in the retina. A number of studies inferred that the angiogenic abilities of NTN4 could contribute to stabilize vascular networks and modulate inflammation. Analyzing human specimens, we show that
Identifiants
pubmed: 33923095
pii: ijms22094481
doi: 10.3390/ijms22094481
pmc: PMC8123351
pii:
doi:
Substances chimiques
NTN4 protein, human
0
Netrins
0
Ntn4 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Dr. Margot Engelmann Stiftung
ID : N/A
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