Transcriptome Analysis Reveals Differential Gene Expression between the Closing Ductus Arteriosus and the Patent Ductus Arteriosus in Humans.
congenital heart disease
ductus arteriosus
neointima
neural crest
transcriptome
tunica media
Journal
Journal of cardiovascular development and disease
ISSN: 2308-3425
Titre abrégé: J Cardiovasc Dev Dis
Pays: Switzerland
ID NLM: 101651414
Informations de publication
Date de publication:
16 Apr 2021
16 Apr 2021
Historique:
received:
08
03
2021
revised:
08
04
2021
accepted:
14
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
The ductus arteriosus (DA) immediately starts closing after birth. This dynamic process involves DA-specific properties, including highly differentiated smooth muscle, sparse elastic fibers, and intimal thickening (IT). Although several studies have demonstrated DA-specific gene expressions using animal tissues and human fetuses, the transcriptional profiles of the closing DA and the patent DA remain largely unknown. We performed transcriptome analysis using four human DA samples. The three closing DA samples exhibited typical DA morphology, but the patent DA exhibited aorta-like elastic lamellae and poorly formed IT. A cluster analysis revealed that samples were clearly divided into two major clusters, the closing DA and patent DA clusters, and showed distinct gene expression profiles in IT and the tunica media of the closing DA samples. Cardiac neural crest-related genes such as
Identifiants
pubmed: 33923468
pii: jcdd8040045
doi: 10.3390/jcdd8040045
pmc: PMC8073410
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Japan Society for the Promotion of Science
ID : JP18K15681
Organisme : Japan Society for the Promotion of Science
ID : JP16H07107
Organisme : Japan Society for the Promotion of Science
ID : JP20K17730
Organisme : Japan Society for the Promotion of Science
ID : JP17K08976
Organisme : Japan Society for the Promotion of Science
ID : JP20H03650
Organisme : Japan Society for the Promotion of Science
ID : JP20K21638
Organisme : Japan Society for the Promotion of Science
ID : JP18K08767
Organisme : Japan Agency for Medical Research and Development
ID : 20ek0210117h0002
Organisme : the Lydia O'Leary Memorial Pias Dermatological Foundation
ID : NA
Organisme : Miyata Cardiac Research Promotion Foundation
ID : NA
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