Induction of Axonal Outgrowth in Mouse Hippocampal Neurons via Bacterial Magnetosomes.
axonal elongation
magnetosomes
stretch-growth
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Apr 2021
16 Apr 2021
Historique:
received:
11
03
2021
revised:
12
04
2021
accepted:
13
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
13
5
2021
Statut:
epublish
Résumé
Magnetosomes are membrane-enclosed iron oxide crystals biosynthesized by magnetotactic bacteria. As the biomineralization of bacterial magnetosomes can be genetically controlled, they have become promising nanomaterials for bionanotechnological applications. In the present paper, we explore a novel application of magnetosomes as nanotool for manipulating axonal outgrowth via stretch-growth (SG). SG refers to the process of stimulation of axonal outgrowth through the application of mechanical forces. Thanks to their superior magnetic properties, magnetosomes have been used to magnetize mouse hippocampal neurons in order to stretch axons under the application of magnetic fields. We found that magnetosomes are avidly internalized by cells. They adhere to the cell membrane, are quickly internalized, and slowly degrade after a few days from the internalization process. Our data show that bacterial magnetosomes are more efficient than synthetic iron oxide nanoparticles in stimulating axonal outgrowth via SG.
Identifiants
pubmed: 33923565
pii: ijms22084126
doi: 10.3390/ijms22084126
pmc: PMC8072586
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Research Council
ID : grant agreement No. 692637
Pays : International
Organisme : Wings for Life Foundation
ID : WFL-IT-16/17
Organisme : Federal Ministry of Education and Research
ID : Grant MagBioFab
Références
Langmuir. 2019 Jun 11;35(23):7423-7431
pubmed: 30110535
Contrast Media Mol Imaging. 2018 Jul 11;2018:2198703
pubmed: 30116160
J Phys Condens Matter. 2008 Sep 24;20(38):385214
pubmed: 21693832
PLoS One. 2019 Apr 23;14(4):e0215657
pubmed: 31013301
Biomaterials. 2017 Mar;121:167-178
pubmed: 28088078
Theranostics. 2017 Oct 13;7(18):4618-4631
pubmed: 29158849
Int J Mol Sci. 2020 Oct 28;21(21):
pubmed: 33126477
J Bacteriol. 2014 Jul;196(14):2658-69
pubmed: 24816605
Biophys J. 2018 Nov 20;115(10):2026-2033
pubmed: 30473016
Adv Biosyst. 2020 Mar;4(3):e1900231
pubmed: 32293150
Adv Drug Deliv Rev. 2019 Jan 1;138:302-325
pubmed: 30639256
Molecules. 2018 Sep 24;23(10):
pubmed: 30249983
Appl Environ Microbiol. 2004 Feb;70(2):1040-50
pubmed: 14766587
J Bacteriol. 2020 Oct 8;202(21):
pubmed: 32817094
J Cell Sci. 1979 Jun;37:391-410
pubmed: 479327
Biomaterials. 2017 Jan;115:53-64
pubmed: 27888699
Nanomedicine. 2014 Oct;10(7):1549-58
pubmed: 24407149
mBio. 2015 Jan 13;6(1):
pubmed: 25587011
Front Cell Neurosci. 2015 Sep 16;9:359
pubmed: 26441530
Sci Rep. 2020 Jul 14;10(1):11540
pubmed: 32665608
Sci Rep. 2016 Jun 01;6:26961
pubmed: 27246808
Small. 2020 Apr;16(16):e1906922
pubmed: 32187836
Biotechnol Bioeng. 2008 Dec 15;101(6):1313-20
pubmed: 18980188
Dev Biol. 1984 Apr;102(2):379-89
pubmed: 6706005
PLoS One. 2011;6(6):e21442
pubmed: 21738665
Acta Biomater. 2021 Jan 15;120:293-303
pubmed: 32721577
ACS Synth Biol. 2020 Feb 21;9(2):392-401
pubmed: 31922737
Appl Microbiol Biotechnol. 2003 Jun;61(5-6):536-44
pubmed: 12764570
Biomaterials. 2012 Aug;33(22):5650-7
pubmed: 22571804
Prog Biophys Mol Biol. 2003 May-Jul;82(1-3):81-95
pubmed: 12732270
Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19042-7
pubmed: 22065745
Appl Environ Microbiol. 2014 Apr;80(8):2609-16
pubmed: 24532068
Nat Rev Microbiol. 2016 Sep 13;14(10):621-37
pubmed: 27620945
Science. 1995 Sep 15;269(5230):1578-80
pubmed: 7667637
PLoS One. 2014 Oct 07;9(10):e108959
pubmed: 25289664
J Neurosci. 2020 Jun 24;40(26):4997-5007
pubmed: 32444384
Front Bioeng Biotechnol. 2014 Mar 11;2:5
pubmed: 25152880
Cytometry A. 2009 Apr;75(4):371-6
pubmed: 18937344
Front Cell Neurosci. 2015 Aug 05;9:292
pubmed: 26300729
Nanotoxicology. 2010 Sep;4(3):271-83
pubmed: 20795909
Nanoscale. 2017 May 11;9(18):5788-5793
pubmed: 28447690
Nanomedicine. 2015 Apr;11(3):559-67
pubmed: 25596077
Bone Joint Res. 2020 May 16;9(1):1-14
pubmed: 32435450
Appl Environ Microbiol. 2008 Aug;74(15):4944-53
pubmed: 18539817
Appl Environ Microbiol. 2001 Oct;67(10):4573-82
pubmed: 11571158
J Neurosci. 1991 Apr;11(4):1117-25
pubmed: 2010807
Small. 2006 Nov;2(11):1251-5
pubmed: 17192969
Arch Microbiol. 2003 Jan-Feb;179(2):89-94
pubmed: 12560986
J Proteomics. 2018 Feb 10;172:89-99
pubmed: 29054541
Prog Neurobiol. 2009 Nov;89(3):231-9
pubmed: 19664679
Adv Drug Deliv Rev. 2008 Aug 17;60(11):1252-65
pubmed: 18558452
Annu Rev Microbiol. 2009;63:501-21
pubmed: 19575557
Faraday Discuss. 2015;181:71-83
pubmed: 25932467
ACS Appl Mater Interfaces. 2018 Nov 7;10(44):37898-37910
pubmed: 30360046