Gut Microbiota and Environment in Coronary Artery Disease.
Western diet
coronary artery disease
gut microbiota
lipopolysaccharides
pollution
short-chain fatty acids
trimethylamine-N-oxide
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
16 04 2021
16 04 2021
Historique:
received:
31
03
2021
accepted:
14
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
21
5
2021
Statut:
epublish
Résumé
In recent years, studies evaluated the associations between coronary artery disease (CAD) and fecal gut microbiota composition. This opens new perspectives on therapeutic strategies to prevent CAD representing the leading cause of mortality in Western societies. We have conducted a review of the literature regarding the characteristics of the gut microbiota of CAD patients, its underlying mechanisms and their associations with pollution and the Western diet. The latest evidence confirms that an abnormal microbiota predisposes to the development of CAD and differs in composition compared to the microbiota of healthy patients; the results are, however, heterogeneous. The most studied underlying mechanisms involve the production of trimethylamine-N-oxide (TMAO), the synthesis of short-chain fatty acids (SCFAs) and the immune system activation mediated by lipopolysaccharides (LPS). Despite a large amount of available data, there is no evidence about the role of a specific type of gut microbiota in the risk of developing acute coronary syndrome (ACS). Moreover, no relationship has been assessed between the gut microbiota and the characteristics of coronary plaques in humans. However, a close association has been found between both pollution and the Western diet and gut microbiota and CAD. Further studies are needed to clarify the associations between gut microbiota, CAD, and ACS to find efficient therapeutic strategies.
Identifiants
pubmed: 33923612
pii: ijerph18084242
doi: 10.3390/ijerph18084242
pmc: PMC8073779
pii:
doi:
Substances chimiques
Fatty Acids, Volatile
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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