Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions.
GSH
Nrf2
TIGAR
heme oxygenase
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
16 04 2021
16 04 2021
Historique:
received:
18
03
2021
revised:
07
04
2021
accepted:
14
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
21
9
2021
Statut:
epublish
Résumé
Heme-oxygenase is the enzyme responsible for degradation of endogenous iron protoporphyirin heme; it catalyzes the reaction's rate-limiting step, resulting in the release of carbon monoxide (CO), ferrous ions, and biliverdin (BV), which is successively reduced in bilirubin (BR) by biliverdin reductase. Several studies have drawn attention to the controversial role of HO-1, the enzyme inducible isoform, pointing out its implications in cancer and other diseases development, but also underlining the importance of its antioxidant activity. The contribution of HO-1 in redox homeostasis leads to a relevant decrease in cells oxidative damage, which can be reconducted to its cytoprotective effects explicated alongside other endogenous mechanisms involving genes like
Identifiants
pubmed: 33923744
pii: biom11040589
doi: 10.3390/biom11040589
pmc: PMC8072688
pii:
doi:
Substances chimiques
Heme Oxygenase-1
EC 1.14.14.18
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Catania, Programma Ricerca di Ateneo UNICT 2020-22 linea 2
ID : 57722172126
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