Imbalance of Mg Homeostasis as a Potential Biomarker in Colon Cancer.
X-ray fluorescence microscopy
colon cancer
magnesium
magnesium homeostasis
magnesium transporters
synchrotron light source
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
20 Apr 2021
20 Apr 2021
Historique:
received:
09
03
2021
revised:
12
04
2021
accepted:
15
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Increasing evidences support a correlation between magnesium (Mg) homeostasis and colorectal cancer (CRC). Nevertheless, the role of Mg and its transporters as diagnostic markers in CRC is still a matter of debate. In this study we combined X-ray Fluorescence Microscopy and databases information to investigate the possible correlation between Mg imbalance and CRC. CRC tissue samples and their non-tumoural counterpart from four patients were collected and analysed for total Mg level and distribution by X-Ray Fluorescence Microscopy. We also reviewed the scientific literature and the main tissue expression databases to collect data on Mg transporters expression in CRC. We found a significantly higher content of total Mg in CRC samples when compared to non-tumoural tissues. Mg distribution was also impaired in CRC. Conversely, we evidenced an uncertain correlation between Mg transporters expression and colon malignancies. Although further studies are necessary to determine the correlation between different cancer types and stages, this is the first report proposing the measurement of Mg tissue localisation as a marker in CRC. This study represents thus a proof-of-concept that paves the way for the design of a larger prospective investigation of Mg in CRC.
Sections du résumé
BACKGROUND
BACKGROUND
Increasing evidences support a correlation between magnesium (Mg) homeostasis and colorectal cancer (CRC). Nevertheless, the role of Mg and its transporters as diagnostic markers in CRC is still a matter of debate. In this study we combined X-ray Fluorescence Microscopy and databases information to investigate the possible correlation between Mg imbalance and CRC.
METHODS
METHODS
CRC tissue samples and their non-tumoural counterpart from four patients were collected and analysed for total Mg level and distribution by X-Ray Fluorescence Microscopy. We also reviewed the scientific literature and the main tissue expression databases to collect data on Mg transporters expression in CRC.
RESULTS
RESULTS
We found a significantly higher content of total Mg in CRC samples when compared to non-tumoural tissues. Mg distribution was also impaired in CRC. Conversely, we evidenced an uncertain correlation between Mg transporters expression and colon malignancies.
DISCUSSION
CONCLUSIONS
Although further studies are necessary to determine the correlation between different cancer types and stages, this is the first report proposing the measurement of Mg tissue localisation as a marker in CRC. This study represents thus a proof-of-concept that paves the way for the design of a larger prospective investigation of Mg in CRC.
Identifiants
pubmed: 33923883
pii: diagnostics11040727
doi: 10.3390/diagnostics11040727
pmc: PMC8073761
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Cancer Treat Rev. 2009 Jun;35(4):378-82
pubmed: 19203841
Clin Sci (Lond). 2012 Oct;123(7):417-27
pubmed: 22671428
Curr Biol. 2018 Dec 17;28(24):R1403-R1405
pubmed: 30562536
World J Gastroenterol. 2019 Oct 14;25(38):5732-5772
pubmed: 31636470
Magnes Res. 1992 Sep;5(3):189-92
pubmed: 1467157
Eur J Clin Nutr. 2012 Nov;66(11):1182-6
pubmed: 23031849
Cancer Biomark. 2019;26(4):451-460
pubmed: 31640089
Rocz Panstw Zakl Hig. 2013;64(3):165-71
pubmed: 24325082
Pharmaceuticals (Basel). 2017 Apr 05;10(2):
pubmed: 28379203
Curr Biol. 2018 Dec 17;28(24):3984-3991.e5
pubmed: 30528584
Magnes Res. 2014 Jan-Mar;27(1):25-34
pubmed: 24776097
Anal Bioanal Chem. 2018 Jan;410(2):337-348
pubmed: 29150807
Histopathology. 2020 Jan;76(2):182-188
pubmed: 31433515
Biol Trace Elem Res. 2019 Jun;189(2):325-335
pubmed: 30171595
Adv Chronic Kidney Dis. 2018 May;25(3):224-229
pubmed: 29793660
Clin Cancer Res. 2008 Jul 1;14(13):4219-24
pubmed: 18594003
Metallomics. 2018 Jul 18;10(7):917-928
pubmed: 29952392
Anal Chem. 2014 May 20;86(10):5108-15
pubmed: 24734900
Cell Biosci. 2020 Mar 10;10:31
pubmed: 32175074
Lancet. 2019 Oct 19;394(10207):1467-1480
pubmed: 31631858
Nutrients. 2021 Jan 13;13(1):
pubmed: 33450887
Magnes Res. 2012 Jul-Sep;25(3):104-11
pubmed: 23009862
Cell Calcium. 2019 Nov;83:102078
pubmed: 31493712
J Clin Invest. 2014 Dec;124(12):5398-410
pubmed: 25347473
Magnes Res. 2011 Sep;24(3):S92-100
pubmed: 21933757
Front Biosci. 2006 Sep 01;11:3149-63
pubmed: 16720382
Biochim Biophys Acta. 2005 May 15;1744(1):19-28
pubmed: 15878394
Int J Mol Sci. 2020 Mar 09;21(5):
pubmed: 32182937
Nat Genet. 2002 Jun;31(2):166-70
pubmed: 12032568
Mol Cancer Res. 2007 Dec;5(12):1263-75
pubmed: 18171984
Crystals (Basel). 2020 Jan;10(1):
pubmed: 33163227
J Nutr. 2016 Mar;146(3):595-602
pubmed: 26865651
Lancet Oncol. 2007 May;8(5):387-94
pubmed: 17466895
Magnes Res. 2011 Dec;24(4):163-80
pubmed: 22064327
Cancer Genomics Proteomics. 2012 Mar-Apr;9(2):67-75
pubmed: 22399497
Dig Liver Dis. 2020 Oct;52(10):1188-1194
pubmed: 32505565
Cancers (Basel). 2013 Jun 05;5(2):676-713
pubmed: 24216997
Oncol Lett. 2019 Oct;18(4):3857-3862
pubmed: 31516596
Curr Drug Targets. 2019;20(12):1217-1226
pubmed: 31215384
NPJ Precis Oncol. 2019 Mar 6;3:7
pubmed: 30854468
Clin Cancer Res. 2007 Feb 15;13(4):1107-14
pubmed: 17317818
Ann Oncol. 2011 May;22(5):1141-1146
pubmed: 21115601
World J Gastroenterol. 2014 Jun 14;20(22):6786-808
pubmed: 24944469
Nat Protoc. 2017 Mar;12(3):461-471
pubmed: 28151463
Anticancer Drugs. 2020 Sep;31(8):856-865
pubmed: 32639280
Arch Biochem Biophys. 2000 Feb 15;374(2):395-401
pubmed: 10666323
Anal Bioanal Chem. 2011 Aug;401(3):853-64
pubmed: 21533642
Magnes Res. 2013 Oct-Dec;26(4):149-55
pubmed: 24556627
Nature. 2011 Jul 27;475(7357):471-6
pubmed: 21796205
Magnes Res. 2008 Jun;21(2):83-91
pubmed: 18705535
Nutrients. 2020 Jun 19;12(6):
pubmed: 32575600
Front Biosci. 2007 Jan 01;12:308-31
pubmed: 17127301
Nat Rev Gastroenterol Hepatol. 2020 Feb;17(2):111-130
pubmed: 31900466
Sci Rep. 2015 Nov 13;5:16538
pubmed: 26563869
Oncol Rep. 2018 Dec;40(6):3551-3560
pubmed: 30272358
Cancer Epidemiol Biomarkers Prev. 2019 Aug;28(8):1292-1299
pubmed: 31167754
Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt A):1000-1008
pubmed: 28192171
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Health Phys. 2012 Aug;103(2):181-6
pubmed: 22951477
Biol Trace Elem Res. 2018 May;183(1):1-8
pubmed: 28795369
Int J Mol Sci. 2019 Apr 16;20(8):
pubmed: 30995736
Carcinogenesis. 2013 Feb;34(2):361-9
pubmed: 23125223
Biomed Opt Express. 2017 Sep 05;8(10):4331-4347
pubmed: 29082068
J Synchrotron Radiat. 2016 Nov 1;23(Pt 6):1526-1537
pubmed: 27787260
Med Sci (Basel). 2019 Apr 04;7(4):
pubmed: 30987399
J Exp Clin Cancer Res. 2019 Feb 28;38(1):106
pubmed: 30819230
Am J Clin Nutr. 2012 Sep;96(3):622-31
pubmed: 22854408
Phys Med Biol. 2009 Feb 7;54(3):651-63
pubmed: 19131671