Viral Infection Modulates Mitochondrial Function.
apoptosis
host innate immunity
mitochondrial fission and fusion
virus infection
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Apr 2021
20 Apr 2021
Historique:
received:
30
03
2021
revised:
14
04
2021
accepted:
15
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
25
5
2021
Statut:
epublish
Résumé
Mitochondria are important organelles involved in metabolism and programmed cell death in eukaryotic cells. In addition, mitochondria are also closely related to the innate immunity of host cells against viruses. The abnormality of mitochondrial morphology and function might lead to a variety of diseases. A large number of studies have found that a variety of viral infections could change mitochondrial dynamics, mediate mitochondria-induced cell death, and alter the mitochondrial metabolic status and cellular innate immune response to maintain intracellular survival. Meanwhile, mitochondria can also play an antiviral role during viral infection, thereby protecting the host. Therefore, mitochondria play an important role in the interaction between the host and the virus. Herein, we summarize how viral infections affect microbial pathogenesis by altering mitochondrial morphology and function and how viruses escape the host immune response.
Identifiants
pubmed: 33923929
pii: ijms22084260
doi: 10.3390/ijms22084260
pmc: PMC8073244
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Science and Technology Program of Guangzhou, China
ID : 201803020005
Organisme : the Science and Technology Program of Guangdong, China
ID : 2019B020211003
Organisme : the Major Program of Guangdong Basic and Applied Research
ID : 202019071850100001
Organisme : the Key Research Projects of Universities in Guangdong Province
ID : 2019KZDXM026
Organisme : 111 Project
ID : D20008
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