Mineralocorticoid Receptor Antagonists Eplerenone and Spironolactone Modify Adrenal Cortex Morphology and Physiology.

adrenal cortex eplerenone mineralocorticoid receptor antagonists spironolactone steroids

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
20 Apr 2021
Historique:
received: 26 03 2021
revised: 14 04 2021
accepted: 17 04 2021
entrez: 30 4 2021
pubmed: 1 5 2021
medline: 1 5 2021
Statut: epublish

Résumé

Mineralocorticoid receptor antagonists (MRAs) are a class of anti-hypertensive drugs that act by blocking aldosterone action. The aim of this study was to evaluate whether the MRAs spironolactone and eplerenone influence adrenal cortical physiology and morphology. Spontaneous hypertensive rats (SHR,

Identifiants

pubmed: 33924172
pii: biomedicines9040441
doi: 10.3390/biomedicines9040441
pmc: PMC8074383
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDB/00215/2020
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDP/00215/2020

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Auteurs

Sofia S Pereira (SS)

Department of Anatomy and Unit for Multidisciplinary Biomedical Research (UMIB) of Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.

Liliana Carvalho (L)

Department of Experimental Biology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.

Madalena M Costa (MM)

Department of Anatomy and Unit for Multidisciplinary Biomedical Research (UMIB) of Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.

Armindo Melo (A)

Department of Environmental Health, National Institute of Health Dr. Ricardo Jorge, 4000-055 Porto, Portugal.
Laboratório Associado Para a Química Verde (LAQV/REQUIMTE), University of Porto, 4050-313 Porto, Portugal.

Isabel M P L V O Ferreira (IMPLVO)

Laboratório Associado Para a Química Verde (LAQV/REQUIMTE), University of Porto, 4050-313 Porto, Portugal.
Laboratory of Bromatology and Hidrology, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.

Celso E Gomez-Sanchez (CE)

Endocrinology Section, G.V. (Sonny) Montgomery VA Medical Center, Montgomery, AL 36109, USA.
Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.

Mariana P Monteiro (MP)

Department of Anatomy and Unit for Multidisciplinary Biomedical Research (UMIB) of Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.

Gavin Vinson (G)

The School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK.

Duarte Pignatelli (D)

Department of Experimental Biology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
Cancer Signalling & Metabolism Group, Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal.
Cancer Signalling & Metabolism Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-135 Porto, Portugal.
Department of Endocrinology, Hospital S. João, 4200-319 Porto, Portugal.

Classifications MeSH