Magnetic Nanoparticle-Based Dianthin Targeting for Controlled Drug Release Using the Endosomal Escape Enhancer SO1861.
EGF
SO1861
drug delivery
endosomal escape
functionalization
saponin
surface modification
targeted toxin
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
20 Apr 2021
20 Apr 2021
Historique:
received:
16
03
2021
revised:
13
04
2021
accepted:
14
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Targeted tumor therapy can provide the basis for the inhibition of tumor growth. However, a number of toxin-based therapeutics lack efficacy because of insufficient endosomal escape after being internalized by endocytosis. To address this problem, the potential of glycosylated triterpenoids, such as SO1861, as endosomal escape enhancers (EEE) for superparamagnetic iron oxide nanoparticle (SPION)-based toxin therapy was investigated. Herein, two different SPION-based particle systems were synthesized, each selectively functionalized with either the targeted toxin, dianthin-epidermal growth factor (DiaEGF), or the EEE, SO1861. After applying both particle systems in vitro, an almost 2000-fold enhancement in tumor cell cytotoxicity compared to the monotherapy with SPION-DiaEGF and a 6.7-fold gain in specificity was observed. Thus, the required dose of the formulation was appreciably reduced, and the therapeutic window widened.
Identifiants
pubmed: 33924180
pii: nano11041057
doi: 10.3390/nano11041057
pmc: PMC8074366
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Biochem Pharmacol. 2015 Oct 1;97(3):247-55
pubmed: 26253687
Bioorg Med Chem. 2013 Apr 15;21(8):2387-2395
pubmed: 23454223
Mol Oncol. 2017 Nov;11(11):1527-1543
pubmed: 28755527
Invest Radiol. 2006 Mar;41(3):313-24
pubmed: 16481915
Chin J Cancer. 2011 Jan;30(1):5-12
pubmed: 21192840
Toxins (Basel). 2019 Oct 11;11(10):
pubmed: 31614697
Oncologist. 2002;7 Suppl 4:31-9
pubmed: 12202786
J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:300-304
pubmed: 29202361
J Control Release. 2016 May 10;229:130-139
pubmed: 26993425
Br J Pharmacol. 2010 Jan 1;159(2):345-52
pubmed: 20015087
Blood. 2014 Apr 17;123(16):2470-7
pubmed: 24578503
Mol Oncol. 2012 Jun;6(3):323-32
pubmed: 22309811
Photochem Photobiol Sci. 2015 Aug;14(8):1433-50
pubmed: 25805311
Cancer Control. 2007 Jul;14(3):295-304
pubmed: 17615536
Clin Diagn Lab Immunol. 1994 Jul;1(4):365-72
pubmed: 8556470
Macromol Rapid Commun. 2016 Mar;37(5):439-45
pubmed: 26691543
Oncol Lett. 2011 Nov;2(6):1131-1137
pubmed: 22121396
Eur J Pharm Biopharm. 2015 Jan;89:365-73
pubmed: 25536111
Invest Radiol. 2005 Nov;40(11):715-24
pubmed: 16230904
Toxins (Basel). 2016 May 04;8(5):
pubmed: 27153091
Immunopharmacology. 1997 Oct;37(2-3):117-32
pubmed: 9403331
Mini Rev Med Chem. 2008 Jun;8(6):575-84
pubmed: 18537712
Int J Cancer. 2010 Sep 1;127(6):1453-61
pubmed: 20020492
Future Oncol. 2014 Nov;10(14):2161-75
pubmed: 25471031
Int J Cancer. 2019 Apr 15;144(8):1941-1953
pubmed: 30350310
Bioconjug Chem. 2019 Feb 20;30(2):263-272
pubmed: 30452233
Clin Cancer Res. 2003 Apr;9(4):1274-83
pubmed: 12684395
Crit Rev Oncol Hematol. 1995 Jul;19(3):183-232
pubmed: 7612182
Nat Nanotechnol. 2010 Jan;5(1):42-7
pubmed: 19893516
Cancer Chemother Pharmacol. 2006 Jun;57(6):709-18
pubmed: 16320055
Nat Rev Cancer. 2006 Jul;6(7):559-65
pubmed: 16794638
Chem Soc Rev. 2012 Apr 7;41(7):2718-39
pubmed: 22389111
Curr Drug Targets. 2009 Feb;10(2):140-51
pubmed: 19199910
Drug Discov Today. 2012 Jul;17(13-14):774-83
pubmed: 22484096
J Biophotonics. 2020 Mar;13(3):e201960090
pubmed: 31721451
Theranostics. 2012;2(1):86-102
pubmed: 22272222
Protein Expr Purif. 2013 Sep;91(1):54-60
pubmed: 23867360
Langmuir. 2021 Jan 12;37(1):171-179
pubmed: 33355468
Nanomedicine. 2012 Apr;8(3):275-90
pubmed: 21930108
Planta Med. 2016 Dec;82(18):1525-1531
pubmed: 27392242
Biomedicines. 2017 Mar 29;5(2):
pubmed: 28536357
Nanoscale. 2014 Jun 21;6(12):6415-25
pubmed: 24837409
Small. 2013 May 27;9(9-10):1450-66
pubmed: 23233377
Nanomedicine. 2005 Sep;1(3):193-212
pubmed: 17292079