Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke.
Animals
Aquaporin 4
/ genetics
Astrocytes
/ metabolism
Biomarkers
Blood-Brain Barrier
/ metabolism
Brain
/ blood supply
Cerebrovascular Circulation
Disease Management
Disease Susceptibility
Gene Expression Regulation
Humans
Ischemic Stroke
/ etiology
Neovascularization, Pathologic
Neurogenesis
Neuroglia
/ metabolism
Neurons
/ metabolism
Neuroprotection
astrocyte
neuroinflammation
neuroprotection
neurorestoration
neurotoxicity
neurovascular
secretion
stroke
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Apr 2021
20 Apr 2021
Historique:
received:
07
03
2021
revised:
11
04
2021
accepted:
15
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
26
5
2021
Statut:
epublish
Résumé
Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and cognitive deficits. Despite promising pre-clinical studies, clinically approved neuroprotective therapies are lacking. Most studies have focused on neurons while ignoring the important roles of other cells of the neurovascular unit, such as astrocytes and pericytes. Astrocytes are important for the development and maintenance of the blood-brain barrier, brain homeostasis, structural support, control of cerebral blood flow and secretion of neuroprotective factors. Emerging data suggest that astrocyte activation exerts both beneficial and detrimental effects following ischaemic stroke. Activated astrocytes provide neuroprotection and contribute to neurorestoration, but also secrete inflammatory modulators, leading to aggravation of the ischaemic lesion. Astrocytes are more resistant than other cell types to stroke pathology, and exert a regulative effect in response to ischaemia. These roles of astrocytes following ischaemic stroke remain incompletely understood, though they represent an appealing target for neurovascular protection following stroke. In this review, we summarise the astrocytic contributions to neurovascular damage and repair following ischaemic stroke, and explore mechanisms of neuroprotection that promote revascularisation and neurorestoration, which may be targeted for developing novel therapies for ischaemic stroke.
Identifiants
pubmed: 33924191
pii: ijms22084280
doi: 10.3390/ijms22084280
pmc: PMC8074612
pii:
doi:
Substances chimiques
Aquaporin 4
0
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellocme Trust
ID : 200633/z/16/z
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