Effect of Goal-Directed Crystalloid versus Colloid Administration on Perioperative Hemostasis in Partial Hepatectomy: A Randomized, Controlled Trial.
abdominal surgery
colloids
goal-directed fluid management
perioperative hemostasis
viscoelastic coagulation tests
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
13 Apr 2021
13 Apr 2021
Historique:
received:
03
03
2021
revised:
27
03
2021
accepted:
09
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
The use of colloids may impair hemostatic capacity. However, it remains unclear whether this also holds true when colloids are administered in a goal-directed manner. The aim of the present study was to assess the effect of goal-directed fluid management with 6% hydroxyethyl starch 130/0.4 on hemostasis compared to lactated Ringer's solution in patients undergoing partial hepatectomy. We included 50 patients in this prospective, randomized, controlled trial. According to randomization, patients received boluses of either hydroxyethyl starch or lactated Ringer's solution within the scope of goal-directed fluid management. Minimum perioperative FIBTEM maximum clot firmness (MCF) served as the primary outcome parameter. Secondary outcome parameters included fibrinogen levels and estimated blood loss. In the hydroxyethyl starch (HES) group the minimum FIBTEM MCF value was significantly lower (effect size -6 mm, 95% CI -10 to -3,
Identifiants
pubmed: 33924407
pii: jcm10081651
doi: 10.3390/jcm10081651
pmc: PMC8068812
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fresenius Kabi Austria
ID : N/A
Organisme : Deltex Medical
ID : N/A
Organisme : Department of Anaesthesia, Intensive Care Medicine and Pain Medicine
ID : N/A
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