Molecular Characterization and Seroprevalence of Hepatitis E Virus in Inflammatory Bowel Disease Patients and Solid Organ Transplant Recipients.
Adolescent
Adult
Aged
Aged, 80 and over
Animals
Cell Line
Female
Haplorhini
Hepatitis E
/ diagnosis
Hepatitis E virus
/ isolation & purification
Humans
Immunocompromised Host
Inflammatory Bowel Diseases
/ virology
Lithuania
/ epidemiology
Male
Mice
Middle Aged
Organ Transplantation
/ adverse effects
Prevalence
Risk Factors
Seroepidemiologic Studies
Swine
Transplant Recipients
Young Adult
Crohn’s disease
MARC-145
biological therapy
genotype 3
hepatitis E
immunosuppression
inflammatory bowel disease
solid organ transplant
ulcerative colitis
zoonosis
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
13 04 2021
13 04 2021
Historique:
received:
15
03
2021
revised:
01
04
2021
accepted:
05
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
19
8
2021
Statut:
epublish
Résumé
Seroprevalence rates and molecular characterization of hepatitis E virus (HEV) prevalent in the Lithuanian human population has not yet been evaluated. Immunosuppressed individuals have been recognized as a risk group for chronic hepatitis due to HEV genotype 3 (HEV-3) infections. The objectives of the present study were to determine prevalence rates of anti-HEV antibodies among inflammatory bowel disease (IBD) patients and solid organ transplant (SOT) recipients, to isolate and characterize HEV strain present in the Lithuanian human population, and to investigate its capacity to infect non-human primate (MARC-145 and Vero), swine (PK-15) and murine (Neuro-2a) cells in vitro. In the present study, the significant difference of anti-HEV IgG prevalence between healthy (3.0% (95% CI 0-6.3)) and immunosuppressed individuals (12.0% [95% CI 8.1-15.9]) was described. Moreover, our findings showed that anti-HEV IgG seropositivity can be significantly predicted by increasing age (OR = 1.032,
Identifiants
pubmed: 33924409
pii: v13040670
doi: 10.3390/v13040670
pmc: PMC8070591
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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