Individual Lymphocyte Sensitivity to Steroids as a Reliable Biomarker for Clinical Outcome after Steroid Withdrawal in Japanese Renal Transplantation.
biomarker
lymphocyte sensitivity
renal transplantation
steroid reduction
steroid withdrawal
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
13 Apr 2021
13 Apr 2021
Historique:
received:
09
03
2021
revised:
09
04
2021
accepted:
10
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Recently, steroid reduction/withdrawal regimens have been attempted to minimize the side effects of steroids in renal transplantation. However, some recipients have experienced an increase/resumption of steroid administrations and acute graft rejection (AR). Therefore, we investigated the relationship between the individual lymphocyte sensitivity to steroids and the clinical outcome after steroid reduction/withdrawal. We cultured peripheral blood mononuclear cells (PBMCs) isolated from 24 recipients with concanavalin A (Con A) in the presence of methylprednisolone (MPSL) or cortisol (COR) for four days, and the 50% of PBMC proliferation (IC
Identifiants
pubmed: 33924724
pii: jcm10081670
doi: 10.3390/jcm10081670
pmc: PMC8070672
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Transplantation. 2017 Oct;101(10):2590-2598
pubmed: 28376034
Am J Transplant. 2013 Apr;13(4):961-970
pubmed: 23432755
Transplantation. 2007 Feb 15;83(3):277-81
pubmed: 17297401
Clin Transplant. 2018 Sep;32(9):e13381
pubmed: 30098053
Transplant Proc. 2001 Nov-Dec;33(7-8):3174-5
pubmed: 11750362
BMC Med. 2017 Jan 12;15(1):8
pubmed: 28077142
Transplantation. 1994 Nov 27;58(10):1119-30
pubmed: 7974720
Ann Surg. 2008 Oct;248(4):564-77
pubmed: 18936569
Transplant Proc. 2010 Jun;42(5):1643-7
pubmed: 20620492
Clin Transplant. 2000 Aug;14(4 Pt 1):323-8
pubmed: 10945203
Clin J Am Soc Nephrol. 2017 Jan 6;12(1):131-139
pubmed: 27979979
Transplantation. 2004 Nov 27;78(10):1548-56
pubmed: 15599321
Cochrane Database Syst Rev. 2016 Aug 22;(8):CD005632
pubmed: 27546100
Transplantation. 2011 Jun 27;91(12):1386-91
pubmed: 21508898
Saudi J Kidney Dis Transpl. 2019 Nov-Dec;30(6):1398-1406
pubmed: 31929287
Biol Pharm Bull. 2011;34(10):1578-83
pubmed: 21963498
Transplantation. 1991 Feb;51(2):338-42
pubmed: 1825242
Transplant Proc. 2016 Jan-Feb;48(1):42-9
pubmed: 26915841
Am J Kidney Dis. 1999 May;33(5):829-39
pubmed: 10213637
Transpl Int. 2018 Feb;31(2):175-186
pubmed: 28926143
Clin Transplant. 2017 Feb;31(2):
pubmed: 27888534