Study of Cytotoxic and Photodynamic Activities of Dyads Composed of a Zinc Phthalocyanine Appended to an Organotin.
chemotherapy
photodynamic therapy
tin complex
zinc (II) phthalocyanine
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
28 Apr 2021
28 Apr 2021
Historique:
received:
06
04
2021
accepted:
19
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
The combination of photodynamic therapy and chemotherapy is a promising strategy to enhance cancer therapeutic efficacy and reduce drug resistance. In this study two zinc(II) phthalocyanine-tin(IV) conjugates linked by a triethylene glycol chain were synthesized and characterized. In these complexes, the zinc(II) phthalocyanine was used as a potential photosensitizer for PDT and the tin complex was selected as cytostatic moiety. The two dyads composed of zinc(II) phthalocyanine and tin complexes exhibited high cytotoxicity, in absence of light stimulation, against MCF-7 human breast cancer cells with low LC
Identifiants
pubmed: 33924752
pii: ph14050413
doi: 10.3390/ph14050413
pmc: PMC8145453
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Campus France
ID : Eiffel grant
Organisme : Conseil régionnal Pays de la Loire
ID : Lumomat
Organisme : CNRS-L
ID : IT fellowship
Organisme : Lebanese University
ID : IT fellowship
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