An Update on Cholera Immunity and Current and Future Cholera Vaccines.

cholera cholera control mucosal immunity oral cholera vaccine

Journal

Tropical medicine and infectious disease
ISSN: 2414-6366
Titre abrégé: Trop Med Infect Dis
Pays: Switzerland
ID NLM: 101709042

Informations de publication

Date de publication:
28 04 2021
Historique:
received: 10 03 2021
revised: 16 04 2021
accepted: 17 04 2021
entrez: 30 4 2021
pubmed: 1 5 2021
medline: 1 5 2021
Statut: epublish

Résumé

Individual resistance to cholera infection and disease depends on both innate host factors and adaptive immunity acquired by a previous infection or vaccination. Locally produced, intestinal-mucosal secretory IgA (SIgA) antibodies against bacterial surface lipopolysaccharide (LPS) O antigens and/or secreted cholera toxins are responsible for the protective adaptive immunity, in conjunction with an effective mucosal immunologic memory that can elicit a rapid anamnestic SIgA antibody response upon re-exposure to the antigen/pathogen even many years later. Oral cholera vaccines (OCVs), based on inactivated

Identifiants

pubmed: 33925118
pii: tropicalmed6020064
doi: 10.3390/tropicalmed6020064
pmc: PMC8167659
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom

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Auteurs

Jan Holmgren (J)

University of Gothenburg Vaccine Research Institute, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
University of Gothenburg Vaccine Research Institute, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.

Classifications MeSH