Effects of Overexpression of Neurosecretory Protein GL-Precursor Gene on Glucose Homeostasis and Insulin Sensitivity in Mice.
Animals
Blood Glucose
/ metabolism
Diet, High-Fat
Disease Models, Animal
Energy Metabolism
/ genetics
Glucose
/ metabolism
Glucose Tolerance Test
Homeostasis
Insulin
/ metabolism
Insulin Resistance
/ genetics
Male
Mice
Mice, Inbred C57BL
Nerve Tissue Proteins
/ genetics
Neuropeptides
/ metabolism
Obesity
/ metabolism
glucose homeostasis
hypothalamus
insulin sensitivity
neuropeptide
neurosecretory protein GL
obesity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Apr 2021
28 Apr 2021
Historique:
received:
27
03
2021
revised:
24
04
2021
accepted:
26
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
9
6
2021
Statut:
epublish
Résumé
A high-fat diet (HFD) quickly induces obesity with insulin resistance and hyperglycemia. We previously reported that a novel hypothalamic small protein, named neurosecretory protein GL (NPGL), stimulates feeding and fat accumulation in mice. However, the effects of NPGL on insulin sensitivity and glucose homeostasis remain unknown. Hence, we subjected NPGL-precursor gene (
Identifiants
pubmed: 33925193
pii: ijms22094681
doi: 10.3390/ijms22094681
pmc: PMC8125475
pii:
doi:
Substances chimiques
Blood Glucose
0
Insulin
0
Nerve Tissue Proteins
0
Neuropeptides
0
neurosecretory protein GL, mouse
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : JSPS KAKENHI Grant
ID : JP20K22741 to K.F., JP19K06768 to E.I.-U., and JP19H03258 to K.U.
Organisme : the Takeda Science Foundation
ID : none
Organisme : the Uehara Memorial Foundation
ID : none
Organisme : the Ono Medical Research Foundation
ID : none
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