BLBP Is Both a Marker for Poor Prognosis and a Potential Therapeutic Target in Paediatric Ependymoma.

BLBP FABP7 PPAR brain tumor docosahexanoic acid drug resistance ependymoma invasion

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
27 Apr 2021
Historique:
received: 29 03 2021
accepted: 23 04 2021
entrez: 30 4 2021
pubmed: 1 5 2021
medline: 1 5 2021
Statut: epublish

Résumé

Paediatric ependymomas are aggressive, treatment-resistant tumours with a tendency towards relapse, consistent with a sub-population of therapy-resistant cancer stem cells. These cells are believed to derive from brain lipid binding protein (BLBP)-expressing radial glia, hence we proposed that BLBP may be a marker for ependymoma therapy resistance. BLBP protein expression correlated with reduced overall survival (OS) in patients from two trials (CNS9204, a chemotherapy-led infant trial-5 y OS 45% vs. 80%,

Identifiants

pubmed: 33925302
pii: cancers13092100
doi: 10.3390/cancers13092100
pmc: PMC8123630
pii:
doi:

Types de publication

Journal Article

Langues

eng

Références

Oncol Rep. 2011 May;25(5):1307-12
pubmed: 21399875
Cancer Cell. 2005 Oct;8(4):323-35
pubmed: 16226707
J Neurooncol. 2007 Sep;84(3):245-8
pubmed: 17415524
J Biol Chem. 2010 Nov 19;285(47):37005-15
pubmed: 20834042
Int J Oncol. 2016 Jan;48(1):110-4
pubmed: 26530115
Int J Oncol. 2015;46(6):2649-55
pubmed: 25825023
Oncotarget. 2014 Jun 15;5(11):3622-35
pubmed: 25004114
Cancer Cell. 2015 May 11;27(5):728-43
pubmed: 25965575
J Neurooncol. 1992 Jul;13(3):283-90
pubmed: 1517804
Nature. 2014 Feb 27;506(7489):451-5
pubmed: 24553141
Eur J Cancer. 2009 Jul;45(10):1815-23
pubmed: 19427780
PLoS One. 2012;7(12):e52113
pubmed: 23284888
BMJ Open. 2019 Sep 17;9(9):e030502
pubmed: 31530611
Neuro Oncol. 2011 Jan;13(1):70-83
pubmed: 20978004
Lipids. 1996 Dec;31(12):1283-8
pubmed: 8972462
J Negat Results Biomed. 2011 May 31;10:7
pubmed: 21627842
Lipids Health Dis. 2015 Feb 18;14:9
pubmed: 25888960
Nat Rev Cancer. 2005 Apr;5(4):275-84
pubmed: 15803154
Neuro Oncol. 2010 Jun;12(6):580-94
pubmed: 20511191
Genes Dev. 2005 May 1;19(9):1028-33
pubmed: 15879553
Mol Cancer Res. 2009 Jun;7(6):765-86
pubmed: 19531565
Nat Protoc. 2007;2(2):329-33
pubmed: 17406593
Cancer Prev Res (Phila). 2014 Aug;7(8):824-34
pubmed: 24866178
Curr Mol Med. 2011 Aug;11(6):503-11
pubmed: 21663587
BMC Cancer. 2008 Sep 30;8:276
pubmed: 18826602
Acta Neuropathol. 2012 Aug;124(2):247-57
pubmed: 22526017
Clin Cancer Res. 2012 Apr 1;18(7):2001-11
pubmed: 22338015
Sci Rep. 2019 Jul 16;9(1):10290
pubmed: 31311995
Pathol Res Pract. 2010 Feb 15;206(2):98-101
pubmed: 19608352
Biomol NMR Assign. 2009 Jun;3(1):89-93
pubmed: 19636954
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Lancet Oncol. 2014 Jan;15(1):35-47
pubmed: 24314616
J Nutr. 2008 Dec;138(12):2510-4
pubmed: 19022980
Breast Cancer Res Treat. 2013 Oct;141(3):341-52
pubmed: 24062211
Acta Neuropathol Commun. 2014 May 30;2:57
pubmed: 24887326
Brain Pathol. 2012 Nov;22(6):848-60
pubmed: 22568867
Adv Biol Regul. 2019 Jan;71:206-218
pubmed: 30245263
Lancet Oncol. 2009 Mar;10(3):258-66
pubmed: 19274783
Clin Cancer Res. 2014 Nov 15;20(22):5630-40
pubmed: 25398846
In Vitro Cell Dev Biol Anim. 2018 Feb;54(2):156-162
pubmed: 29288341

Auteurs

Durgagauri H Sabnis (DH)

Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK.

Jo-Fen Liu (JF)

Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK.

Lucy Simmonds (L)

Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK.

Sophie Blackburn (S)

Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK.

Richard G Grundy (RG)

Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK.

Ian D Kerr (ID)

School of Life Sciences, QMC, University of Nottingham, Nottingham NG7 2UH, UK.

Beth Coyle (B)

Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK.

Classifications MeSH