Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models.
autoimmune hepatitis
autoimmunity
drug-induced liver injury
genetics
inflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Apr 2021
27 Apr 2021
Historique:
received:
03
04
2021
revised:
22
04
2021
accepted:
23
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
8
6
2021
Statut:
epublish
Résumé
Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly because of its ability to present with a variety of phenotypes including that of autoimmune hepatitis or other immune mediated liver injuries. Limited diagnostic and therapeutic tools are available, mostly because its pathogenesis has remained poorly understood for decades. The recent scientific and technological advancements in genomics and immunology are paving the way for a better understanding of the molecular aspects of DILI. This review provides an updated overview of the genetic predisposition and immunological mechanisms behind the pathogenesis of DILI and presents the state-of-the-art experimental models to study DILI at the pre-clinical level.
Identifiants
pubmed: 33925355
pii: ijms22094557
doi: 10.3390/ijms22094557
pmc: PMC8123708
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Immunol. 1999 Feb 15;162(4):2347-52
pubmed: 9973514
Hepatology. 2015 Sep;62(3):887-99
pubmed: 25998949
Mod Pathol. 2018 Jun;31(6):965-973
pubmed: 29403081
Toxicol Lett. 2015 Jul 2;236(1):16-24
pubmed: 25934330
Nature. 2012 Jun 28;486(7404):554-8
pubmed: 22722860
Blood. 2017 Jun 29;129(26):3419-3427
pubmed: 28424162
Hepatology. 2012 Apr;55(4):1227-36
pubmed: 22031499
Biotechnol J. 2011 May;6(5):554-64
pubmed: 21259441
Gastroenterology. 2019 May;156(6):1707-1716.e2
pubmed: 30664875
Am J Physiol. 1998 Sep;275(3):G387-92
pubmed: 9724248
Chem Res Toxicol. 2021 Mar 15;34(3):849-856
pubmed: 33617238
Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1083-8
pubmed: 16687579
Hepatology. 2016 Nov;64(5):1667-1682
pubmed: 27302828
Eur J Cancer. 2021 May;148:76-91
pubmed: 33740500
Int Immunol. 2000 May;12(5):711-9
pubmed: 10784617
Biochem Pharmacol. 2010 Jul 15;80(2):255-61
pubmed: 20359463
Chem Res Toxicol. 2015 Dec 21;28(12):2287-91
pubmed: 26529122
J Clin Endocrinol Metab. 2013 Apr;98(4):1361-75
pubmed: 23471977
Oncologist. 2016 Oct;21(10):1230-1240
pubmed: 27401894
Hepatology. 2013 Apr;57(4):1654-62
pubmed: 23111952
Gastroenterology. 2017 Apr;152(5):1078-1089
pubmed: 28043905
Liver Int. 2019 Oct;39(10):1906-1917
pubmed: 31319011
Adv Pharmacol. 2019;85:221-239
pubmed: 31307588
Differentiation. 2019 Mar - Apr;106:15-22
pubmed: 30844688
Gastroenterology. 2003 Mar;124(3):692-700
pubmed: 12612908
Therapie. 2021 Nov-Dec;76(6):715-723
pubmed: 29609830
Nat Rev Rheumatol. 2014 Oct;10(10):602-11
pubmed: 25003765
J Clin Oncol. 2016 Aug 10;34(23):2698-704
pubmed: 27269947
Toxicology. 2014 Oct 3;324:43-54
pubmed: 25051504
Hepatology. 2013 Feb;57(2):727-39
pubmed: 22987284
Nat Rev Gastroenterol Hepatol. 2021 Apr;18(4):252-268
pubmed: 33335282
Hepatology. 2013 Jan;57(1):373-84
pubmed: 22821628
Nat Rev Drug Discov. 2020 Feb;19(2):131-148
pubmed: 31748707
Curr Pharmacol Rep. 2018 Oct;4(5):346-357
pubmed: 30560047
Cell Mol Immunol. 2018 Nov;15(11):973-982
pubmed: 28504245
Gastroenterology. 2002 Jan;122(1):202-10
pubmed: 11781294
J Clin Transl Hepatol. 2018 Jun 28;6(2):127-134
pubmed: 29951356
Biochem Biophys Res Commun. 2012 Nov 16;428(2):245-51
pubmed: 23079619
Clin Exp Immunol. 2015 Apr;180(1):40-51
pubmed: 25418487
Nature. 2019 Oct;574(7777):200-205
pubmed: 31582858
Nat Rev Immunol. 2013 Mar;13(3):159-75
pubmed: 23435331
J Leukoc Biol. 1997 Jun;61(6):647-53
pubmed: 9201255
Nat Rev Clin Oncol. 2016 Aug;13(8):473-86
pubmed: 27141885
Hepatology. 2008 Jun;47(6):2003-9
pubmed: 18454504
J Comb Chem. 2008 Nov-Dec;10(6):897-913
pubmed: 18855460
ESMO Open. 2017 Oct 26;2(4):e000247
pubmed: 29104763
Arch Toxicol. 2017 Aug;91(8):2849-2863
pubmed: 28612260
Immunol Rev. 2000 Oct;177:134-40
pubmed: 11138771
N Engl J Med. 2015 Jan 22;372(4):320-30
pubmed: 25399552
Clin Gastroenterol Hepatol. 2017 Jan;15(1):103-112.e2
pubmed: 27311619
J Pathol. 2014 Feb;232(3):344-55
pubmed: 24255005
Toxicology. 2009 Oct 1;264(1-2):89-95
pubmed: 19647030
Hepatology. 2013 Jul;58(1):388-96
pubmed: 23258593
Hepatology. 2015 Apr;61(4):1332-42
pubmed: 25283142
J Hepatol. 2019 Jun;70(6):1222-1261
pubmed: 30926241
Chem Biol Interact. 2004 Nov 1;150(1):115-28
pubmed: 15522265
Invest New Drugs. 2013 Aug;31(4):1071-7
pubmed: 23408334
J Clin Oncol. 2014 Apr 1;32(10):1020-30
pubmed: 24590637
Biotechnol Bioeng. 2012 Dec;109(12):3172-81
pubmed: 22688505
J Am Acad Dermatol. 2014 Jul;71(1):161-9
pubmed: 24767731
Chem Res Toxicol. 2020 Nov 16;33(11):2745-2748
pubmed: 33085478
Chem Res Toxicol. 2018 Jun 18;31(6):412-430
pubmed: 29722533
Biomaterials. 2012 Jun;33(18):4565-75
pubmed: 22475531
Protein Cell. 2012 Apr;3(4):246-50
pubmed: 22441839
Clin Med (Lond). 2016 Dec;16(Suppl 6):s104-s109
pubmed: 27956449
Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1269-79
pubmed: 16439473
Tissue Eng. 2006 Aug;12(8):2241-1251
pubmed: 16968164
Am J Pathol. 2014 Jun;184(6):1677-82
pubmed: 24731753
Hepatology. 1998 Oct;28(4):959-70
pubmed: 9755232
Annu Rev Immunol. 2002;20:197-216
pubmed: 11861602
Clin Pharmacol Ther. 2017 Apr;101(4):469-480
pubmed: 27861792
Dig Dis. 2011;29(4):384-90
pubmed: 21894009
Cancers (Basel). 2020 Oct 04;12(10):
pubmed: 33020428
Science. 2002 Apr 12;296(5566):301-5
pubmed: 11951032
Toxicol Sci. 2007 May;97(1):205-13
pubmed: 17150972
Blood. 2017 Jun 8;129(23):3071-3073
pubmed: 28356247
Nat Genet. 2019 Sep;51(9):1339-1348
pubmed: 31427789
Lancet. 2017 Jan 21;389(10066):255-265
pubmed: 27979383
Clin Transl Immunology. 2016 Nov 04;5(11):e113
pubmed: 27990288
Br J Clin Pharmacol. 2016 Jun;81(6):1030-6
pubmed: 26773235
Cancer Treat Rev. 2016 Apr;45:7-18
pubmed: 26922661
Hepatology. 2010 Jun;51(6):2040-8
pubmed: 20512992
Toxicol Sci. 2017 Jul 1;158(1):76-89
pubmed: 28444390
Toxicol Sci. 2020 Nov 1;178(1):115-126
pubmed: 32777075
J Immunol. 2014 Jul 1;193(1):344-53
pubmed: 24890723
Curr Drug Metab. 2018;19(10):830-838
pubmed: 29788883
Chem Res Toxicol. 2015 Aug 17;28(8):1567-73
pubmed: 26154582
Clin Liver Dis. 2020 Feb;24(1):11-23
pubmed: 31753244
J Clin Invest. 2009 Feb;119(2):305-14
pubmed: 19164858
Toxicol Sci. 2018 Apr 1;162(2):655-666
pubmed: 29329425
PLoS One. 2013 Oct 07;8(10):e76211
pubmed: 24116097
Immunol Today. 2000 Nov;21(11):573-83
pubmed: 11094262
Blood. 2017 Sep 7;130(10):1189-1197
pubmed: 28461396
N Engl J Med. 2015 May 21;372(21):2006-17
pubmed: 25891304
Pharmacogenomics J. 2016 Apr;16(2):180-5
pubmed: 25987243
Allergy. 2021 Jan;76(1):150-167
pubmed: 32383256
Toxicol Sci. 2007 Nov;100(1):259-66
pubmed: 17709330
Sci Rep. 2020 Mar 20;10(1):5124
pubmed: 32198411
Gastroenterology. 2012 Nov;143(5):1158-1172
pubmed: 22982943
Exp Cell Res. 2018 Feb 1;363(1):15-25
pubmed: 29291400
Eur J Immunol. 1996 Jan;26(1):42-8
pubmed: 8566082
J Hepatol. 2015 Jul;63(1):148-55
pubmed: 25681556
Cell Mol Immunol. 2019 Aug;16(8):706-717
pubmed: 30030493
J Leukoc Biol. 2004 Dec;76(6):1089-90; author reply 1091-2
pubmed: 15331625
Toxicol Sci. 2012 May;127(1):187-98
pubmed: 22331495
FASEB J. 1999 Nov;13(14):1883-900
pubmed: 10544172
Arch Toxicol. 2020 Oct;94(10):3381-3407
pubmed: 32852569
Toxicol Appl Pharmacol. 2003 Dec 1;193(2):218-27
pubmed: 14644624
Toxicol Sci. 2013 Mar;132(1):107-17
pubmed: 23152190
Hepatology. 2014 Apr;59(4):1564-76
pubmed: 24282114
J Leukoc Biol. 2008 Dec;84(6):1410-21
pubmed: 18713872
Biochem Pharmacol. 2010 Apr 1;79(7):1036-44
pubmed: 19925779
Semin Liver Dis. 2014 May;34(2):194-204
pubmed: 24879983
Minerva Gastroenterol (Torino). 2023 Mar;69(1):61-83
pubmed: 33267568
Immunity. 2004 Oct;21(4):539-50
pubmed: 15485631
FASEB J. 2017 Jun;31(6):2696-2708
pubmed: 28264975
Cell Death Dis. 2020 Jan 27;11(1):70
pubmed: 31988281
Mol Pharmacol. 2021 Feb;99(2):92-103
pubmed: 33262251
Hepatology. 2006 Jun;43(6):1220-30
pubmed: 16729305
Sci Rep. 2016 May 04;6:25187
pubmed: 27143246
N Engl J Med. 2015 Sep 24;373(13):1270-1
pubmed: 26398076
J Hepatol. 2021 Jul;75(1):177-189
pubmed: 33631227
Toxicol Sci. 2015 Jun;145(2):252-62
pubmed: 25716675
Nat Rev Immunol. 2020 Nov;20(11):651-668
pubmed: 32433532
Nat Commun. 2019 Mar 6;10(1):1076
pubmed: 30842418
Chem Res Toxicol. 2011 Sep 19;24(9):1345-410
pubmed: 21702456
Toxicol Pathol. 2007 Oct;35(6):757-66
pubmed: 17943649
Hepatology. 2013 Apr;57(4):1575-84
pubmed: 23150232
JHEP Rep. 2020 Aug 11;2(6):100170
pubmed: 33205034
Nat Med. 2020 Oct;26(10):1541-1548
pubmed: 32895570
Lancet Oncol. 2014 Jan;15(1):69-77
pubmed: 24332512
Genome Med. 2018 Nov 22;10(1):87
pubmed: 30466478
N Engl J Med. 2019 Jul 18;381(3):264-273
pubmed: 31314970
Nat Rev Cancer. 2012 Mar 22;12(4):252-64
pubmed: 22437870
Toxicol Appl Pharmacol. 2014 Mar 1;275(2):122-33
pubmed: 24440789
Exp Biol Med (Maywood). 2016 Jan;241(1):101-14
pubmed: 26202373
Immunology. 2010 Mar;129(3):363-74
pubmed: 19922426
J Hepatol. 2021 Jul;75(1):86-97
pubmed: 33539847
J Immunol. 1987 Mar 1;138(5):1377-82
pubmed: 3492549
Chem Biol Interact. 2007 May 20;168(1):66-73
pubmed: 17241619
J Pharmacol Exp Ther. 2002 Feb;300(2):460-7
pubmed: 11805205
Gut. 2018 Feb;67(2):333-347
pubmed: 28450389
Immunity. 2016 Mar 15;44(3):450-462
pubmed: 26982353
Biotechnol Adv. 2014 Mar-Apr;32(2):504-13
pubmed: 24440487
Toxicol Sci. 2012 Jan;125(1):126-33
pubmed: 21984482
Hepatology. 2012 Aug;56(2):735-46
pubmed: 22334567
Toxicol In Vitro. 2013 Sep;27(6):1979-86
pubmed: 23850984
Sci Signal. 2018 Apr 17;11(526):
pubmed: 29666305
Food Chem Toxicol. 2016 Dec;98(Pt B):107-118
pubmed: 27773698
Cell Biol Toxicol. 2016 Feb;32(1):37-59
pubmed: 27027780
Drug Metab Dispos. 2017 Apr;45(4):419-429
pubmed: 28137721
N Engl J Med. 2013 Jul 11;369(2):134-44
pubmed: 23724846
Biomark Med. 2014;8(2):201-13
pubmed: 24521015
J Clin Oncol. 2015 Dec 1;33(34):4015-22
pubmed: 26351349
Gastroenterology. 2016 Dec;151(6):1087-1095
pubmed: 27725145
Front Immunol. 2018 Feb 08;9:161
pubmed: 29472923
Toxicol Sci. 2018 Jun 1;163(2):655-665
pubmed: 29590495
Cell Immunol. 2008 Jan;251(1):50-5
pubmed: 18423430
Lab Invest. 2018 Jan;98(1):51-62
pubmed: 28920945
Eur J Immunol. 1997 Jun;27(6):1303-7
pubmed: 9209477