Biomarkers of Low-Level Environmental Exposure to Benzene and Oxidative DNA Damage in Primary School Children in Sardinia, Italy.
benzene
biological monitoring
children
environmental exposure
genotoxicity
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
27 04 2021
27 04 2021
Historique:
received:
08
03
2021
revised:
09
04
2021
accepted:
23
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
28
5
2021
Statut:
epublish
Résumé
The main anthropic sources of exposure to airborne benzene include vehicular traffic, cigarette smoke, and industrial emissions. To detect early genotoxic effects of environmental exposure to benzene, we monitored environmental, personal, and indoor airborne benzene in children living in an urban area and an area near a petrochemical plant. We also used urinary benzene and S-phenylmercapturic acid (S-PMA) as biomarkers of benzene exposure and urinary 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of early genotoxic effects. Although always below the European Union limit of 5 μg/m Our results suggest the importance of biological monitoring of low-level environmental exposure and its relation to risk of genotoxic effects among children.
Sections du résumé
BACKGROUND
The main anthropic sources of exposure to airborne benzene include vehicular traffic, cigarette smoke, and industrial emissions.
METHODS
To detect early genotoxic effects of environmental exposure to benzene, we monitored environmental, personal, and indoor airborne benzene in children living in an urban area and an area near a petrochemical plant. We also used urinary benzene and S-phenylmercapturic acid (S-PMA) as biomarkers of benzene exposure and urinary 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of early genotoxic effects.
RESULTS
Although always below the European Union limit of 5 μg/m
CONCLUSIONS
Our results suggest the importance of biological monitoring of low-level environmental exposure and its relation to risk of genotoxic effects among children.
Identifiants
pubmed: 33925535
pii: ijerph18094644
doi: 10.3390/ijerph18094644
pmc: PMC8123794
pii:
doi:
Substances chimiques
Biomarkers
0
Benzene
J64922108F
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Chem Biol Interact. 2005 May 30;153-154:43-53
pubmed: 15935799
Toxicol Lett. 2010 Jan 15;192(1):17-21
pubmed: 19628029
Environ Sci Pollut Res Int. 2017 Jun;24(16):13885-13894
pubmed: 26971514
Mutat Res. 2004 Mar;566(2):99-130
pubmed: 15164977
J Toxicol Environ Health A. 2015;78(17):1133-6
pubmed: 26460693
Environ Res. 2015 Oct;142:461-70
pubmed: 26257031
Sci Total Environ. 2013 Oct 1;463-464:639-46
pubmed: 23838057
Biochim Biophys Acta. 2014 Feb;1840(2):801-8
pubmed: 23791936
Sci Total Environ. 2017 May 15;586:1279-1286
pubmed: 28236484
Crit Rev Toxicol. 2013 Feb;43(2):119-53
pubmed: 23346981
Sci Total Environ. 2018 Feb 1;613-614:492-501
pubmed: 28918281
Environ Res. 2017 Jan;152:165-174
pubmed: 27771571
Environ Res. 2017 Jan;152:207-213
pubmed: 27792945
Environ Int. 2010 Oct;36(7):779-87
pubmed: 20591482
Toxicol Rep. 2017 May 31;4:291-295
pubmed: 28959652
Environ Pollut. 2017 Mar;222:486-494
pubmed: 28063708
Environ Int. 2012 Feb;39(1):2-7
pubmed: 22208737
Chemosphere. 2010 Sep;81(3):306-11
pubmed: 20696463
J Chromatogr B Biomed Sci Appl. 1999 Feb 19;723(1-2):105-15
pubmed: 10080638
Mutagenesis. 2013 May;28(3):315-21
pubmed: 23446175
Chemosphere. 2008 Dec;74(1):64-9
pubmed: 18922558
Mutat Res Genet Toxicol Environ Mutagen. 2014 Aug;770:61-5
pubmed: 25344165
Epidemiol Rev. 1996;18(2):188-204
pubmed: 9021312
Environ Res. 2015 Oct;142:264-72
pubmed: 26186134
Clin Chem. 1986 Mar;32(3):446-52
pubmed: 3948388
J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Dec 5;844(2):322-7
pubmed: 16908224
Int Arch Occup Environ Health. 2014;87(7):793-9
pubmed: 24370553
Korean J Anesthesiol. 2013 May;64(5):402-6
pubmed: 23741561
Sci Total Environ. 2018 Dec 15;645:974-983
pubmed: 30248884
Environ Health Perspect. 1996 Dec;104 Suppl 6:1123-8
pubmed: 9118881
Int Arch Occup Environ Health. 2009 Aug;82(8):985-95
pubmed: 19009306
Int Arch Occup Environ Health. 2016 Nov;89(8):1289-1297
pubmed: 27568022
Environ Mol Mutagen. 2008 Dec;49(9):695-707
pubmed: 18800353
Toxicol Lett. 2010 Jan 15;192(1):22-8
pubmed: 19427373
Biomarkers. 2011 Jun;16(4):334-45
pubmed: 21417625
Environ Sci Pollut Res Int. 2016 Feb;23(4):3503-16
pubmed: 26490929
Environ Pollut. 2017 Dec;231(Pt 1):681-693
pubmed: 28850936
J Sep Sci. 2017 Jan;40(2):550-557
pubmed: 27860299
Scand J Work Environ Health. 2000 Feb;26(1):62-6
pubmed: 10744179
Saf Health Work. 2017 Jun;8(2):220-225
pubmed: 28593080
Mutat Res Genet Toxicol Environ Mutagen. 2014 Aug;770:55-60
pubmed: 25344164
BMJ Open. 2020 Nov 3;10(11):e037163
pubmed: 33148724
Occup Environ Med. 2001 Jan;58(1):2-13
pubmed: 11119628
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39
pubmed: 19412858
J Environ Monit. 2011 Oct;13(10):2921-8
pubmed: 21909569
Redox Biol. 2019 Jan;20:556-565
pubmed: 30508700
BMJ Open. 2013 Feb 26;3(2):
pubmed: 23444447
Chem Biol Interact. 2008 Apr 15;172(3):185-94
pubmed: 18282563
Regul Toxicol Pharmacol. 2012 Feb;62(1):62-73
pubmed: 22178585
ScientificWorldJournal. 2011;11:2536-49
pubmed: 22235184
Chem Biol Interact. 2005 May 30;153-154:253-6
pubmed: 15935823
Sci Total Environ. 2014 Mar 1;473-474:537-48
pubmed: 24388904
J Environ Monit. 2008 Aug;10(8):941-50
pubmed: 18688463
Occup Environ Med. 2010 May;67(5):341-7
pubmed: 20447988
Carcinogenesis. 2008 May;29(5):977-83
pubmed: 18332047
Sci Total Environ. 2010 Jun 15;408(14):2840-9
pubmed: 20417546
J Occup Environ Hyg. 2009 Sep;6(9):517-29
pubmed: 19544135
Annu Rev Public Health. 2010;31:133-48 2 p following 148
pubmed: 20070208
Sci Total Environ. 2015 Dec 1;536:362-367
pubmed: 26231768