Identification of CRYAB
BMP
NOTCH1 pathway
brain tumors
cellular heterogeneity
diffuse IDH1-mutant gliomas
diffuse grade II IDH-mutant glioma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
27 Apr 2021
27 Apr 2021
Historique:
received:
03
02
2021
revised:
18
04
2021
accepted:
21
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Diffuse grade II IDH-mutant gliomas are slow-growing brain tumors that progress into high-grade gliomas. They present intratumoral cell heterogeneity, and no reliable markers are available to distinguish the different cell subtypes. The molecular mechanisms underlying the formation of this cell diversity is also ill-defined. Here, we report that SOX9 and OLIG1 transcription factors, which specifically label astrocytes and oligodendrocytes in the normal brain, revealed the presence of two largely nonoverlapping tumoral populations in IDH1-mutant oligodendrogliomas and astrocytomas. Astrocyte-like SOX9
Identifiants
pubmed: 33925547
pii: cancers13092107
doi: 10.3390/cancers13092107
pmc: PMC8123787
pii:
doi:
Types de publication
Journal Article
Langues
eng
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