An Experimental Approach to Study the Effects of Realistic Environmental Mixture of Linuron and Propamocarb on Zebrafish Synaptogenesis.
mixtures
pesticides
sublethal effects
synaptogenesis
zebrafish
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
27 04 2021
27 04 2021
Historique:
received:
01
04
2021
revised:
24
04
2021
accepted:
25
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
26
5
2021
Statut:
epublish
Résumé
The reasons behind the extensive use of pesticides include the need to destroy vector organisms and promote agricultural production in order to sustain population growth. Exposure to pesticides is principally occupational, even if their persistence in soil, surface water and food brings the risk closer to the general population, hence the demand for risk assessment, since these compounds exist not only as individual chemicals but also in form of mixtures. In light of this, zebrafish represents a suitable model for the evaluation of toxicological effects. Here, zebrafish embryos were exposed for 96 h post fertilization (hpf) to sublethal concentrations (350 µg/L) of linuron and propamocarb, used separately and then combined in a single solution. We investigated the effects on morphological traits and the expression of genes known to be implicated in synaptogenesis (
Identifiants
pubmed: 33925709
pii: ijerph18094664
doi: 10.3390/ijerph18094664
pmc: PMC8124988
pii:
doi:
Substances chimiques
Carbamates
0
Pesticides
0
Water Pollutants, Chemical
0
Linuron
01XP1SU59O
propamocarb
8HLL7N9UWO
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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