Blood Platelets as an Important but Underrated Circulating Source of TGFβ.
Blood Platelets
/ metabolism
Cardiovascular Diseases
/ physiopathology
Hemostasis
/ physiology
Humans
Inflammation
/ physiopathology
Liver Cirrhosis
/ physiopathology
Malaria, Cerebral
/ physiopathology
Neoplasm Metastasis
/ physiopathology
Platelet Activation
/ physiology
Thrombosis
/ physiopathology
Transforming Growth Factor beta
/ blood
Smad
TGFβ
cardiovascular
fibrosis
granules
platelets
preeclampsia
secretion
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Apr 2021
26 Apr 2021
Historique:
received:
25
02
2021
revised:
17
04
2021
accepted:
24
04
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
20
5
2021
Statut:
epublish
Résumé
When treating diseases related primarily to tissue remodeling and fibrosis, it is desirable to regulate TGFβ concentration and modulate its biological effects. The highest cellular concentrations of TGFβ are found in platelets, with about 40% of all TGFβ found in peripheral blood plasma being secreted by them. Therefore, an understanding of the mechanisms of TGFβ secretion from platelets may be of key importance for medicine. Unfortunately, despite the finding that platelets are an important regulator of TGFβ levels, little research has been carried out into the development of platelet-directed therapies that might modulate the TGFβ-dependent processes. Nevertheless, there are some very encouraging reports suggesting that platelet TGFβ may be specifically involved in cardiovascular diseases, liver fibrosis, tumour metastasis, cerebral malaria and in the regulation of inflammatory cell functions. The purpose of this review is to briefly summarize these few, extremely encouraging reports to indicate the state of current knowledge in this topic. It also attempts to better characterize the influence of TGFβ on platelet activation and reactivity, and its shaping of the roles of blood platelets in haemostasis and thrombosis.
Identifiants
pubmed: 33925804
pii: ijms22094492
doi: 10.3390/ijms22094492
pmc: PMC8123509
pii:
doi:
Substances chimiques
Transforming Growth Factor beta
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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