Effects of the hydroalcoholic extract of Rosa damascena on hippocampal long-term potentiation in rats fed high-fat diet.
Antioxidant
High-fat diet
Hippocampus
Long-term potentiation
Rosa damascena
Synaptic plasticity
Journal
The journal of physiological sciences : JPS
ISSN: 1880-6562
Titre abrégé: J Physiol Sci
Pays: Japan
ID NLM: 101262417
Informations de publication
Date de publication:
29 Apr 2021
29 Apr 2021
Historique:
received:
17
09
2020
accepted:
29
03
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
25
12
2021
Statut:
epublish
Résumé
High-fat diets (HFDs) and obesity can cause serious health problems, such as neurodegenerative diseases and cognitive impairments. Consumption of HFD is associated with reduction in hippocampal synaptic plasticity. Rosa damascena (R. damascena) is traditionally used as a dietary supplement for many disorders. This study was carried out to determine the beneficial effect of hydroalcoholic extract of R. damascena on in vivo hippocampal synaptic plasticity (long-term potentiation, LTP) in the perforant pathway (PP)-dentate gyrus (DG) pathway in rats fed with an HFD. Male Wistar rats were randomly assigned to four groups: Control, R. damascena extract (1 g/kg bw daily for 30 days), HFD (for 90 days) and HFD + extract. The population spike (PS) amplitude and slope of excitatory post-synaptic potentials (EPSP) were measured in DG area in response to stimulation applied to the PP. Serum oxidative stress biomarkers [total thiol group (TTG) and superoxide dismutase (SOD)] were measured. The results showed the HFD impaired LTP induction in the PP-DG synapses. This conclusion is supported by decreased EPSP slope and PS amplitude of LTP. R. damascena supplementation in HFD animals enhanced EPSP slope and PS amplitude of LTP in the granular cell of DG. Consumption of HFD decreased TTG and SOD. R. damascena extract consumption in the HFD animals enhanced TTG and SOD. These data indicate that R. damascena dietary supplementation can ameliorate HFD-induced alteration of synaptic plasticity, probably through its significant antioxidant effects and activate signalling pathways, which are critical in controlling synaptic plasticity.
Identifiants
pubmed: 33926383
doi: 10.1186/s12576-021-00797-y
pii: 10.1186/s12576-021-00797-y
pmc: PMC10717342
doi:
Substances chimiques
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
14Subventions
Organisme : Hamadan University of Medical Sciences
ID : Grant Number: 940222778
Références
Res Pharm Sci. 2015 Nov-Dec;10(6):514-22
pubmed: 26779271
Brain Res Bull. 2017 May;131:168-175
pubmed: 28442324
Sci Rep. 2017 Jul 14;7(1):5391
pubmed: 28710347
Scand J Clin Lab Invest. 2004;64(6):599-604
pubmed: 15370466
Metab Brain Dis. 2018 Jun;33(3):725-731
pubmed: 29294234
Neurochem Res. 2017 Nov;42(11):3149-3159
pubmed: 28770438
Neuron. 2013 Oct 30;80(3):704-17
pubmed: 24183021
Contrib Nephrol. 2005;149:240-260
pubmed: 15876848
Metab Brain Dis. 2017 Jun;32(3):827-839
pubmed: 28255862
Br J Pharmacol. 2016 Jul;173(13):2095-110
pubmed: 26472268
Turk J Pharm Sci. 2020 Feb;17(1):99-107
pubmed: 32454767
Cold Spring Harb Perspect Biol. 2015 Jul 01;7(7):a021758
pubmed: 26134321
J Neurosci. 2001 Aug 1;21(15):5484-93
pubmed: 11466419
Neuroscience. 2004;123(2):429-40
pubmed: 14698750
Nat Neurosci. 2000 Nov;3 Suppl:1178-83
pubmed: 11127835
Cell. 2008 Oct 31;135(3):422-35
pubmed: 18984155
Int J Health Sci (Qassim). 2018 May-Jun;12(3):88-93
pubmed: 29896077
Neurochem Res. 2015 Apr;40(4):811-7
pubmed: 25657067
Pak J Biol Sci. 2008 Mar 1;11(5):746-51
pubmed: 18819571
Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2368-73
pubmed: 11842217
J Neurochem. 2010 Sep;114(6):1581-9
pubmed: 20557430
IBRO Rep. 2020 Sep 25;9:241-246
pubmed: 33024878
Chem Soc Rev. 2009 Apr;38(4):1152-61
pubmed: 19421586
Metab Brain Dis. 2017 Aug;32(4):1255-1265
pubmed: 28536937
J Neuroimmunol. 2010 Feb 26;219(1-2):25-32
pubmed: 20004026
Neural Plast. 2018 Apr 10;2018:9235796
pubmed: 29849573
Sci Rep. 2019 Aug 22;9(1):12270
pubmed: 31439894
Oxid Med Cell Longev. 2018 May 10;2018:7043213
pubmed: 29861833
Genes Nutr. 2008 Dec;3(3-4):115-26
pubmed: 18937002
Indian J Exp Biol. 2006 Nov;44(11):910-2
pubmed: 17205713
EMBO J. 2004 Mar 10;23(5):1040-50
pubmed: 14976558
J Tradit Complement Med. 2015 Oct 30;6(1):10-6
pubmed: 26870673
J Physiol Sci. 2019 Nov;69(6):861-873
pubmed: 31392590
Pharm Biol. 2017 Dec;55(1):2065-2073
pubmed: 28832226
J Nat Med. 2013 Jan;67(1):152-8
pubmed: 22484603
Brain Res Bull. 2020 Nov;164:380-391
pubmed: 32942011
Free Radic Biol Med. 2008 Aug 1;45(3):295-305
pubmed: 18457678
Biomed Pharmacother. 2018 Jan;97:503-510
pubmed: 29091901
J Cereb Blood Flow Metab. 2014 Jun;34(6):1001-8
pubmed: 24667917
Ann Neurol. 1997 Nov;42(5):776-82
pubmed: 9392577
Nutrients. 2019 Oct 25;11(11):
pubmed: 31731503
J Neurosci. 1988 May;8(5):1645-55
pubmed: 3367214
Iran J Pharm Res. 2010 Spring;9(2):163-8
pubmed: 24363723
Brain Res. 2013 Nov 20;1539:1-6
pubmed: 24095795
J Environ Pathol Toxicol Oncol. 2012;31(3):193-201
pubmed: 23339694
Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):499-508
pubmed: 27771511
Regul Toxicol Pharmacol. 2016 Nov;81:1-7
pubmed: 27381452
J Toxicol. 2013;2013:769143
pubmed: 24163695
BMC Complement Altern Med. 2010 Dec 16;10:77
pubmed: 21159207
Behav Neural Biol. 1993 Jul;60(1):9-26
pubmed: 8216164
Brain Res Bull. 2018 Mar;137:338-350
pubmed: 29339105
Complement Ther Med. 2017 Oct;34:129-140
pubmed: 28917365
Arch Neurol. 2003 Feb;60(2):194-200
pubmed: 12580703
Neuroscience. 2015 Jun 25;297:170-81
pubmed: 25849614
Free Radic Biol Med. 2009 Nov 15;47(10):1329-38
pubmed: 19715755
Adv Biomed Res. 2015 Jul 27;4:131
pubmed: 26322279
PLoS One. 2015 May 29;10(5):e0128274
pubmed: 26023930
Fitoterapia. 2011 Jun;82(4):513-23
pubmed: 21277359
Brain Res. 2015 Dec 10;1629:270-81
pubmed: 26462654
FASEB J. 2011 Mar;25(3):1088-96
pubmed: 21106937
Brain Res. 2020 Jan 1;1726:146475
pubmed: 31560865
J Physiol Sci. 2020 Mar 24;70(1):19
pubmed: 32209056