A 3D high resolution MRI method for the visualization of cardiac fibro-fatty infiltrations.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
29 04 2021
29 04 2021
Historique:
received:
08
10
2020
accepted:
22
02
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
9
11
2021
Statut:
epublish
Résumé
Modifications of the myocardial architecture can cause abnormal electrical activity of the heart. Fibro-fatty infiltrations have been implicated in various cardiac pathologies associated with arrhythmias and sudden cardiac death, such as arrhythmogenic right ventricular cardiomyopathy (ARVC). Here, we report the development of an MRI protocol to observe these modifications at 9.4 T. Two fixed ex vivo human hearts, one healthy and one ARVC, were imaged with an Iterative decomposition with echo asymmetry and least-square estimations (IDEAL) and a magnetization transfer (MT) 3D sequences. The resulting fat fraction and MT ratio (MTR) were analyzed and compared to histological analysis of the three regions ("ARVC triangle") primarily involved in ARVC structural remodeling. In the ARVC heart, high fat content was observed in the "ARVC triangle" and the superimposition of the MTR and fat fraction allowed the identification of fibrotic regions in areas without the presence of fat. The healthy heart exhibited twice less fat than the ARVC heart (31.9%, 28.7% and 1.3% of fat in the same regions, respectively). Localization of fat and fibrosis were confirmed by means of histology. This non-destructive approach allows the investigation of structural remodeling in human pathologies where fibrosis and/or fatty tissue infiltrations are expected to occur.
Identifiants
pubmed: 33927217
doi: 10.1038/s41598-021-85774-6
pii: 10.1038/s41598-021-85774-6
pmc: PMC8084928
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9266Références
Clin Physiol Funct Imaging. 2005 May;25(3):171-7
pubmed: 15888098
Circulation. 1996 Mar 1;93(5):841-2
pubmed: 8598070
Magn Reson Med. 2007 Aug;58(2):354-64
pubmed: 17654578
Adv Drug Deliv Rev. 2019 Jun;146:77-82
pubmed: 31158407
Circulation. 2019 Apr 9;139(15):1786-1797
pubmed: 30700137
J Comput Assist Tomogr. 1985 Jul-Aug;9(4):659-75
pubmed: 2991345
Phys Med Biol. 1985 Apr;30(4):341-4
pubmed: 4001160
Magn Reson Med. 2005 Sep;54(3):636-44
pubmed: 16092103
Radiology. 2017 Apr;283(1):77-86
pubmed: 27697008
Am J Cardiol. 1986 Sep 1;58(6):568-70
pubmed: 3751926
Circulation. 2019 Oct 29;140(18):1477-1490
pubmed: 31542949
Cardiovasc Pathol. 2004 Nov-Dec;13(6):313-6
pubmed: 15556777
Hum Pathol. 2012 Apr;43(4):592-6
pubmed: 21937076
Magn Reson Med. 1993 Feb;29(2):211-5
pubmed: 8429785
BMC Bioinformatics. 2017 Nov 29;18(1):529
pubmed: 29187165
MAGMA. 2021 Jan 23;:
pubmed: 33484367
Curr Cardiovasc Imaging Rep. 2010 Apr;3(2):83-91
pubmed: 20401158
Invest Radiol. 2017 Nov;52(11):686-692
pubmed: 28542095
Heart Fail Rev. 2017 Jul;22(4):415-430
pubmed: 28623475
Magn Reson Imaging. 2012 Nov;30(9):1323-41
pubmed: 22770690
Magn Reson Med. 1991 Apr;18(2):371-83
pubmed: 2046518
J Arrhythm. 2017 Dec 21;34(1):11-22
pubmed: 29721109
NMR Biomed. 2001 Apr;14(2):57-64
pubmed: 11320533
Cardiovasc Res. 2014 May 1;102(2):205-13
pubmed: 24648445
Curr Opin Cardiol. 2016 Jan;31(1):46-56
pubmed: 26569086
J Am Coll Cardiol. 2001 Dec;38(7):1773-81
pubmed: 11738273
J Cardiovasc Electrophysiol. 2013 Dec;24(12):1311-20
pubmed: 23889974
Nat Clin Pract Cardiovasc Med. 2005 Oct;2(10):536-43
pubmed: 16186852
Circ Arrhythm Electrophysiol. 2018 Jul;11(7):e006120
pubmed: 30002064
Eur Heart J. 2010 Apr;31(7):806-14
pubmed: 20172912
Radiology. 2011 Apr;259(1):127-35
pubmed: 21324841
Magn Reson Med. 2017 Oct;78(4):1452-1457
pubmed: 27790751
J Magn Reson Imaging. 2012 Sep;36(3):529-42
pubmed: 22903654
J Cardiovasc Magn Reson. 2014 Jan 04;16:2
pubmed: 24387626
J Am Chem Soc. 2002 Mar 27;124(12):3125-32
pubmed: 11902901
Heart Rhythm. 2016 Jan;13(1):311-20
pubmed: 26277495
Magn Reson Med. 2013 Jul;70(1):155-9
pubmed: 22887356
J Histochem Cytochem. 1958 Jul;6(4):265-70
pubmed: 13563844
J Magn Reson Imaging. 2008 Sep;28(3):543-58
pubmed: 18777528
J Magn Reson Imaging. 2007 Mar;25(3):644-52
pubmed: 17326087
Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H287-98
pubmed: 22021329
J Hepatol. 2013 Nov;59(5):992-8
pubmed: 23838178
Am J Med. 2004 Nov 1;117(9):685-95
pubmed: 15501207
Clin Med Insights Cardiol. 2015 Mar 09;8(Suppl 4):27-36
pubmed: 25788837
J Magn Reson Imaging. 2010 Jan;31(1):4-18
pubmed: 20027567
Magn Reson Imaging. 1987;5(3):189-99
pubmed: 3041151
J Cardiovasc Magn Reson. 2015 Apr 29;17:31
pubmed: 25926126
PLoS One. 2018 Oct 8;13(10):e0205104
pubmed: 30296279
Circ J. 2015;79(5):901-13
pubmed: 25877738