KLK3 SNP-SNP interactions for prediction of prostate cancer aggressiveness.

Biomarkers, Tumor / genetics Epistasis, Genetic Genetic Predisposition to Disease Genotype Humans Kallikreins / genetics Male Polymorphism, Single Nucleotide Prostate-Specific Antigen / genetics Prostatic Neoplasms / genetics

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
29 04 2021
Historique:
received: 27 10 2020
accepted: 24 02 2021
entrez: 30 4 2021
pubmed: 1 5 2021
medline: 9 11 2021
Statut: epublish

Résumé

Risk classification for prostate cancer (PCa) aggressiveness and underlying mechanisms remain inadequate. Interactions between single nucleotide polymorphisms (SNPs) may provide a solution to fill these gaps. To identify SNP-SNP interactions in the four pathways (the angiogenesis-, mitochondria-, miRNA-, and androgen metabolism-related pathways) associated with PCa aggressiveness, we tested 8587 SNPs for 20,729 cases from the PCa consortium. We identified 3 KLK3 SNPs, and 1083 (P < 3.5 × 10

Identifiants

DOI: 10.1038/s41598-021-85169-7 PMID: 33927218 PMC: PMC8084951
pubmed: 33927218
doi: 10.1038/s41598-021-85169-7
pii: 10.1038/s41598-021-85169-7
pmc: PMC8084951
doi:

Substances chimiques

Biomarkers, Tumor 0
KLK3 protein, human EC 3.4.21.-
Kallikreins EC 3.4.21.-
Prostate-Specific Antigen EC 3.4.21.77

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

9264

Subventions

Organisme : NIH HHS
ID : R21CA202417
Pays : United States
Organisme : NIH HHS
ID : R01CA128813
Pays : United States

Investigateurs

Rosalind Eeles (R)
Zsofia Kote-Jarai (Z)
Kenneth Muir (K)
Judith Clements (J)
Jyotsna Batra (J)
Hui-Yi Lin (HY)
Rosalind Eeles (R)
Zsofia Kote-Jarai (Z)
Kenneth Muir (K)
Johanna Schleutker (J)
Nora Pashayan (N)
David E Neal (DE)
Sune F Nielsen (SF)
Børge G Nordestgaard (BG)
Henrik Gronberg (H)
Fredrik Wiklund (F)
Graham G Giles (GG)
Christopher A Haiman (CA)
Ruth C Travis (RC)
Janet L Stanford (JL)
Adam S Kibel (AS)
Cezary Cybulski (C)
Kay-Tee Khaw (KT)
Christiane Maier (C)
Stephen N Thibodeau (SN)
Manuel R Teixeira (MR)
Lisa Cannon-Albright (L)
Hermann Brenner (H)
Radka Kaneva (R)
Hardev Pandha (H)

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Auteurs

Hui-Yi Lin (HY)

Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA. hlin1@lsuhsc.edu.

Po-Yu Huang (PY)

Computational Intelligence Technology Center, Industrial Technology Research Institute, Hsinchu, Taiwan.

Chia-Ho Cheng (CH)

Department of Biostatistics and Bioinformatics, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.

Heng-Yuan Tung (HY)

Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.

Zhide Fang (Z)

Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.

Anders E Berglund (AE)

Department of Biostatistics and Bioinformatics, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.

Ann Chen (A)

Department of Biostatistics and Bioinformatics, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.

Jennifer French-Kwawu (J)

Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.

Darian Harris (D)

Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.

Julio Pow-Sang (J)

Department of Genitourinary Oncology, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.

Kosj Yamoah (K)

Department of Radiation Oncology, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.

John L Cleveland (JL)

Department of Tumor Biology, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.

Shivanshu Awasthi (S)

Department of Cancer Epidemiology, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.

Robert J Rounbehler (RJ)

Department of Tumor Biology, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.

Travis Gerke (T)

Department of Cancer Epidemiology, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.

Jasreman Dhillon (J)

Department of Pathology, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.

Rosalind Eeles (R)

The Institute of Cancer Research, London, SM2 5NG, UK.
Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.

Zsofia Kote-Jarai (Z)

The Institute of Cancer Research, London, SM2 5NG, UK.

Kenneth Muir (K)

Division of Population Health, Health Services Research, and Primary Care, University of Manchester, Oxford Road, Manchester, M139PT, UK.
Warwick Medical School, University of Warwick, Coventry, UK.

Johanna Schleutker (J)

Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20014, Turku, Finland.
Department of Medical Genetics, Genomics, Laboratory Division, Turku University Hospital, PO Box 52, 20521, Turku, Finland.

Nora Pashayan (N)

Department of Applied Health Research, University College London, London, UK.
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK.
Department of Applied Health Research, University College London, London, WC1E 7HB, UK.

David E Neal (DE)

Nuffield Department of Surgical Sciences, University of Oxford, Room 6603, Level 6, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK.
Department of Oncology, University of Cambridge, Addenbrooke's Hospital, Hills Road, Box 279, Cambridge, CB2 0QQ, UK.

Sune F Nielsen (SF)

Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2200, Copenhagen, Denmark.

Børge G Nordestgaard (BG)

Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2200, Copenhagen, Denmark.

Henrik Gronberg (H)

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

Fredrik Wiklund (F)

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

Graham G Giles (GG)

Cancer Epidemiology Division, Cancer Council Victoria, 615 St Kilda Road, Melbourne, VIC, 3004, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Grattan Street, Parkville, VIC, 3010, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, 3168, Australia.

Christopher A Haiman (CA)

Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90015, USA.

Ruth C Travis (RC)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.

Janet L Stanford (JL)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA.
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, 98195, USA.

Adam S Kibel (AS)

Division of Urologic Surgery, Brigham and Womens Hospital, 75 Francis Street, Boston, MA, 02115, USA.

Cezary Cybulski (C)

Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.

Kay-Tee Khaw (KT)

Clinical Gerontology Unit, University of Cambridge, Cambridge, CB2 2QQ, UK.

Christiane Maier (C)

Humangenetik Tuebingen, Paul-Ehrlich-Str 23, 72076, Tuebingen, Germany.

Stephen N Thibodeau (SN)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.

Manuel R Teixeira (MR)

Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal.
Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal.

Lisa Cannon-Albright (L)

Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, 84148, USA.

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, 69120, Heidelberg, Germany.

Radka Kaneva (R)

Department of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University of Sofia, Sofia, 2 Zdrave Str., 1431, Sofia, Bulgaria.

Hardev Pandha (H)

University of Surrey, Guildford, GU2 7XH, Surrey, UK.

Srilakshmi Srinivasan (S)

Translational Research Institute, Brisbane, QLD, 4102, Australia.
Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, 4059, Australia.

Judith Clements (J)

Translational Research Institute, Brisbane, QLD, 4102, Australia.
Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, 4059, Australia.

Jyotsna Batra (J)

Translational Research Institute, Brisbane, QLD, 4102, Australia.
Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, 4059, Australia.

Jong Y Park (JY)

Department of Cancer Epidemiology, Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › KLK3 SNP-SNP interactions for prediction of...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épistasie › KLK3 SNP-SNP interactions for prediction of...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › KLK3 SNP-SNP interactions for prediction of...
questionsmedicales.fr › Phénomènes génétiques › Génotype › KLK3 SNP-SNP interactions for prediction of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › KLK3 SNP-SNP interactions for prediction of...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Kallicréines › KLK3 SNP-SNP interactions for prediction of...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › KLK3 SNP-SNP interactions for prediction of...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Antigène spécifique de la prostate › KLK3 SNP-SNP interactions for prediction of...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › KLK3 SNP-SNP interactions for prediction of...