Carvedilol Exerts Neuroprotective Effect on Rat Model of Diabetic Neuropathy.
antioxidants
carvedilol
diabetes
diabetic neuropathy
in vivo
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
10
2020
accepted:
24
02
2021
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Diabetic neuropathy (DN) commonly occurs in diabetics, affecting approximately 50% of both type 1 and 2 diabetic patients. It is a leading cause of non-traumatic amputations. Oxidative stress could play a key role in the pathophysiology of DN. This study aimed to investigate the potential neuroprotective effect of carvedilol on STZ-induced DN in rats. Thirty male Sprague Dawley rats (weighing 200-250 g) were randomly divided into five groups (six/group), where group 1 (negative control) received only the vehicle (0.5% of carboxymethyl cellulose orally 1 ml/kg). DN was induced by a single injection of remaining rats with streptozotocin (STZ; 50 mg/kg, i.p.). After diabetes induction, group 2 served as the diabetic untreated animals; while groups 3 and 4 were treated with carvedilol (1 and 10 mg/kg/d, orally, respectively). Group 5 received
Identifiants
pubmed: 33927613
doi: 10.3389/fphar.2021.613634
pii: 613634
pmc: PMC8077026
doi:
Types de publication
Journal Article
Langues
eng
Pagination
613634Informations de copyright
Copyright © 2021 Magadmi, Alsulaimani, Al-Rafiah, Ahmad and Esmat.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Asian Pac J Trop Med. 2016 Sep;9(9):825-831
pubmed: 27633293
Int J Health Sci (Qassim). 2007 Jul;1(2):V-VIII
pubmed: 21475425
Annu Rev Neurosci. 2017 Jul 25;40:307-325
pubmed: 28441116
Exp Neurol. 2014 Nov;261:22-33
pubmed: 24967684
Brain Res. 2000 Jan 31;854(1-2):19-29
pubmed: 10784102
J Neurosci. 2015 Jun 3;35(22):8593-603
pubmed: 26041925
Exp Neurol. 2006 Feb;197(2):430-6
pubmed: 16300761
Eur J Pharmacol. 2006 May 1;536(3):256-61
pubmed: 16584726
Diabetes Res Clin Pract. 2014 Feb;103(2):218-22
pubmed: 24300017
Pharmacol Rep. 2008 Jul-Aug;60(4):499-507
pubmed: 18799818
Nature. 1989 Jan 26;337(6205):362-4
pubmed: 2911387
J Pharmacol Exp Ther. 2007 Jul;322(1):282-7
pubmed: 17431136
Ann Intern Med. 1997 Jun 15;126(12):955-9
pubmed: 9182472
Hypertension. 2001 Apr;37(4):1053-9
pubmed: 11304502
J Diabetes Investig. 2011 Jan 24;2(1):33-42
pubmed: 24843458
FASEB J. 2000 Aug;14(11):1548-58
pubmed: 10928989
Cardiovasc Drugs Ther. 1997 May;11 Suppl 1:247-56
pubmed: 9211017
Pharmacol Biochem Behav. 2009 Mar;92(1):25-31
pubmed: 18992766
Ann Neurol. 1994 Aug;36(2):244-6
pubmed: 8053664
Inflammopharmacology. 2017 Aug;25(4):393-402
pubmed: 28353124
Diabetes Res Clin Pract. 2017 Aug;130:90-97
pubmed: 28582723
Diabetes Technol Ther. 2000 Autumn;2(3):401-13
pubmed: 11467343
Pharmacology. 1989;39(5):327-36
pubmed: 2575762
J Neurosci. 1999 Oct 1;19(19):8509-16
pubmed: 10493751
Clin Geriatr Med. 2008 Aug;24(3):489-501, vi-vii
pubmed: 18672184
Nat Methods. 2014 Jun;11(6):629-32
pubmed: 24776635
Lancet Neurol. 2012 Jun;11(6):521-34
pubmed: 22608666
J Diabetes Res. 2021 Jan 16;2021:6927025
pubmed: 33532503
Diabetes. 2016 Jan;65(1):228-38
pubmed: 26470786
Eur J Neurosci. 1994 Dec 1;6(12):1903-12
pubmed: 7704300
Brain Res. 2000 Jun 9;867(1-2):149-56
pubmed: 10837808
Endocr Rev. 2002 Oct;23(5):599-622
pubmed: 12372842
Curr Neuropharmacol. 2015;13(3):294-303
pubmed: 26411962
Metab Syndr Relat Disord. 2004 Fall;2(3):155-9
pubmed: 18370680
Toxicol Appl Pharmacol. 2013 Apr 15;268(2):241-8
pubmed: 23360886
Neuroreport. 2000 May 15;11(7):1417-20
pubmed: 10841349
Lab Anim. 1993 Jul;27(3):258-69
pubmed: 8366672
Behav Pharmacol. 2016 Sep;27(6):528-35
pubmed: 27392124
Brain Res. 1982 Jul 29;244(2):378-81
pubmed: 6180809
Nat Rev Neurosci. 2009 Apr;10(4):283-94
pubmed: 19259101
J Pharmacol Toxicol Methods. 2016 Mar-Apr;78:13-31
pubmed: 26596652
Expert Opin Pharmacother. 2014 Dec;15(18):2721-31
pubmed: 25381809
Free Radic Biol Med. 1999 Jun;26(11-12):1495-500
pubmed: 10401614
Kaohsiung J Med Sci. 2013 Jan;29(1):19-25
pubmed: 23257252
Indian J Med Res. 2007 Mar;125(3):451-72
pubmed: 17496368
Diabetologia. 2001 Jun;44(6):766-74
pubmed: 11440370
Chem Biol Interact. 2014 Nov 5;223:69-79
pubmed: 25245570
FASEB J. 2002 Nov;16(13):1738-48
pubmed: 12409316
BMC Neurosci. 2005 Jan 24;6:4
pubmed: 15667652
Diabet Med. 1998 Jun;15(6):508-14
pubmed: 9632127
J Neurosci. 2001 Aug 15;21(16):6077-85
pubmed: 11487631
J Hypertens. 2007 Apr;25(4):731-41
pubmed: 17351362
N Engl J Med. 2000 Mar 30;342(13):905-12
pubmed: 10738048
Indian J Exp Biol. 2008 Feb;46(2):108-11
pubmed: 18335808
Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2985-90
pubmed: 17301229
Toxicol Appl Pharmacol. 2017 May 1;322:97-103
pubmed: 28286117
Drug Metab Rev. 1998 May;30(2):245-75
pubmed: 9606603
Indian J Exp Biol. 2006 Jul;44(7):566-9
pubmed: 16872046
Curr Pharm Des. 2011;17(20):2113-29
pubmed: 21718248
Biomed Res Int. 2015;2015:515042
pubmed: 25821809
Ann N Y Acad Sci. 1994 Nov 17;738:230-42
pubmed: 7832432
Diabetes Care. 2005 Apr;28(4):956-62
pubmed: 15793206
Neuroscience. 2014 Feb 14;259:155-63
pubmed: 24316060
Molecules. 2015 Jun 09;20(6):10657-88
pubmed: 26065639
Free Radic Res Commun. 1992;17(3):211-7
pubmed: 1459492
Eur J Clin Invest. 2017 Jan;47(1):19-29
pubmed: 27805735
Eur J Pharmacol. 2015 Oct 5;764:599-606
pubmed: 26054810
Eur J Clin Pharmacol. 1990;38 Suppl 2:S82-8
pubmed: 1974511
J Pharmacol Exp Ther. 1992 Oct;263(1):92-8
pubmed: 1357162
Biochem Biophys Res Commun. 2013 Nov 29;441(4):917-22
pubmed: 24216104
Naunyn Schmiedebergs Arch Pharmacol. 1995 Jun;351(6):630-5
pubmed: 7675122