Superabsorbent poly(acrylic acid) and antioxidant poly(ester amide) hybrid hydrogel for enhanced wound healing.
antioxidant
poly (acrylic acid)/poly (ester amide)
superabsorbent
wound healing
Journal
Regenerative biomaterials
ISSN: 2056-3418
Titre abrégé: Regen Biomater
Pays: England
ID NLM: 101652150
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
13
09
2020
revised:
02
12
2020
accepted:
13
12
2020
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
1
5
2021
Statut:
epublish
Résumé
Wound healing dressing is increasingly needed in clinical owing to the large quantity of skin damage annually. Excessive reactive oxygen species (ROS) produced through internal or external environmental influences can lead to lipid peroxidation, protein denaturation, and even DNA damage, and ultimately have harmful effects on cells. Aiming to sufficiently contact with the wound microenvironment and scavenge ROS, superabsorbent poly (acrylic acid) and antioxidant poly (ester amide) (PAA/PEA) hybrid hydrogel has been developed to enhance wound healing. The physical and chemical properties of hybrid hydrogels were studied by Fourier-transform infrared (FTIR) absorption spectrum, compression, swelling, degradation, etc. Besides, the antioxidant properties of hybrid hydrogels can be investigated through the free radical scavenging experiment, and corresponding antioxidant indicators have been tested at the cellular level. Hybrid hydrogel scaffolds supported the proliferation of human umbilical vein endothelial cells and fibroblasts, as well as accelerated angiogenesis and skin regeneration in wounds. The healing properties of wounds in vivo were further assessed on mouse skin wounds. Results showed that PAA/PEA hybrid hydrogel scaffolds significantly accelerated the wound healing process through enhancing granulation formation and re-epithelialization. In summary, these superabsorbent and antioxidative hybrid hydrogels could be served as an excellent wound dressing for full-thickness wound healing.
Identifiants
pubmed: 33927886
doi: 10.1093/rb/rbaa059
pii: rbaa059
pmc: PMC8055781
doi:
Types de publication
Journal Article
Langues
eng
Pagination
rbaa059Informations de copyright
© The Author(s) 2021. Published by Oxford University Press.
Références
Trends Biotechnol. 2018 Sep;36(9):907-922
pubmed: 29764691
Cent Eur J Immunol. 2017;42(4):370-376
pubmed: 29472815
Front Bioeng Biotechnol. 2020 Mar 19;8:182
pubmed: 32266224
J Control Release. 2020 Aug 10;324:204-217
pubmed: 32389779
ACS Appl Mater Interfaces. 2019 Feb 27;11(8):7703-7714
pubmed: 30714361
J Colloid Interface Sci. 2019 Nov 15;556:514-528
pubmed: 31473541
Adv Healthc Mater. 2015 Mar 11;4(4):569-75
pubmed: 25213436
Int J Mol Sci. 2017 Oct 15;18(10):
pubmed: 29036938
Macromol Biosci. 2014 Mar;14(3):440-50
pubmed: 24821672
Acta Biomater. 2020 Mar 1;104:85-94
pubmed: 31901456
Front Microbiol. 2020 Jun 03;11:998
pubmed: 32582051
ACS Appl Mater Interfaces. 2019 Jan 23;11(3):2908-2916
pubmed: 30596421
Biomaterials. 2020 Aug;249:120020
pubmed: 32305816
Carbohydr Polym. 2020 Aug 1;241:116364
pubmed: 32507198
Acta Biomater. 2020 Apr 15;107:25-49
pubmed: 32084600
J Mater Chem B. 2019 Aug 21;7(33):5019-5037
pubmed: 31432870
Small. 2019 Mar;15(12):e1900046
pubmed: 30786150
Adv Mater. 2019 Feb;31(5):e1804187
pubmed: 30537340
Asian J Pharm Sci. 2020 Nov;15(6):661-684
pubmed: 33363624
Antioxid Redox Signal. 2014 Mar 1;20(7):1126-67
pubmed: 23991888
Circ Res. 2018 Mar 16;122(6):877-902
pubmed: 29700084
Am J Forensic Med Pathol. 2020 Jun;41(2):135-137
pubmed: 32379097
J Invest Dermatol. 2020 Feb;140(2):284-290
pubmed: 31326398
Acta Biomater. 2020 Feb;103:142-152
pubmed: 31846801
Biomater Sci. 2019 Oct 1;7(10):4230-4236
pubmed: 31393463
Biomaterials. 2017 Jul;133:20-28
pubmed: 28414976