Biosynthesis of sulfonamide and sulfamate antibiotics in actinomycete.
Actinomycete
Bioactivity
Biosynthesis
Sulfamates
Sulfonamide
Journal
Journal of industrial microbiology & biotechnology
ISSN: 1476-5535
Titre abrégé: J Ind Microbiol Biotechnol
Pays: Germany
ID NLM: 9705544
Informations de publication
Date de publication:
04 Jun 2021
04 Jun 2021
Historique:
accepted:
21
11
2020
received:
28
09
2020
pubmed:
1
5
2021
medline:
20
7
2021
entrez:
30
4
2021
Statut:
ppublish
Résumé
Sulfonamides and sulfamates are a group of organosulfur compounds that contain the signature sulfamoyl structural motif. These compounds were initially only known as synthetic antibacterial drugs but were later also discovered as natural products. Eight highly potent examples have been isolated from actinomycetes to date, illustrating the large biosynthetic repertoire of this bacterial genus. For the biosynthesis of these compounds, several distinct and unique biosynthetic machineries have been discovered, capable to generate the unique S-N bond. For the creation of novel, second generation natural products by biosynthetic engineering efforts, a detailed understanding of the underlying enzyme machinery toward potent structural motifs is crucial. In this review, we aim to summarize the current state of knowledge on sulfonamide and sulfamate biosynthesis. A detailed discussion for the secondary sulfamate ascamycin, the tertiary sulfonamide sulfadixiamycin A, and the secondary sulfonamide SB-203208 is provided and their bioactivities and mode of actions are discussed.
Identifiants
pubmed: 33928358
pii: 6123731
doi: 10.1093/jimb/kuab001
pmc: PMC9113183
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Biological Products
0
Sulfonamides
0
Sulfonic Acids
0
sulfamic acid
9NFU33906Q
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of Society of Industrial Microbiology and Biotechnology.
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