Effects of acute alcohol consumption on neuronal activity and cerebral vasomotor response.
Acute alcohol consumption
Cerebral vasoreactivity
Neurovascular coupling
Transcranial Doppler
Visual activation
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
11
01
2021
accepted:
19
04
2021
pubmed:
1
5
2021
medline:
6
1
2022
entrez:
30
4
2021
Statut:
ppublish
Résumé
In the majority of European countries, driving after drinking small-moderate amount of alcohol is legal. Motivated by our previous studies on cerebral hemodynamics, we aimed to study whether a small-moderate blood alcohol content (BAC), at which driving is legal in some countries (0.8 g/L), influences the neuronal activity, neurovascular coupling, and cerebral vasoreactivity. Analyses of pattern-reversal visual evoked potential (VEP) and transcranial Doppler (TCD) examinations were performed in thirty young healthy adults before and 30 min after alcohol consumption. Cerebral vasoreactivity was evaluated by breath holding test in both middle cerebral arteries. By using a visual cortex stimulation paradigm, visually evoked flow velocity response during reading was measured in both posterior cerebral arteries (PCA). The BAC was 0.82 g/L and 0.94 g/L 30 and 60 min after drinking alcohol, respectively. Latency of the VEP P100 wave increased after alcohol consumption. Resting absolute flow velocity values increased, whereas pulsatility indices in the PCA decreased after alcohol ingestion, indicating vasodilation of cerebral microvessels. Breath holding index and the visually evoked maximum relative flow velocity increase in the PCA and steepness of rise of the flow velocity curve were smaller after than before alcohol consumption. BAC close to a legal value at which driving is allowed in some European countries inhibited the neuronal activity and resulted in dilation of cerebral arterioles. Cerebral vasodilation may explain the decrease of cerebral vasoreactivity and might contribute to the disturbance of visually evoked flow response after alcohol consumption.
Identifiants
pubmed: 33928457
doi: 10.1007/s10072-021-05273-4
pii: 10.1007/s10072-021-05273-4
pmc: PMC8724078
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
625-631Subventions
Organisme : Hungarian National Brain Research Program
ID : NAP_13-1-2013-0001
Organisme : Hungarian National Brain Research Program
ID : 2017-1.2.1-NKP-2017-00002
Organisme : Economic Development and Innovation Operative Programme
ID : GINOP 2.3.2-15-2016-00043 (Ironheart)
Informations de copyright
© 2021. The Author(s).
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