Heterochromatin and Polycomb as regulators of haematopoiesis.
PRC2
SUV39H1/2
blood cancer
cell differentiation
epigenetic silencing
haematopoietic stem cells
Journal
Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897
Informations de publication
Date de publication:
30 04 2021
30 04 2021
Historique:
received:
28
02
2021
revised:
12
04
2021
accepted:
14
04
2021
pubmed:
1
5
2021
medline:
29
1
2022
entrez:
30
4
2021
Statut:
ppublish
Résumé
Haematopoiesis is the process by which multipotent haematopoietic stem cells are transformed into each and every type of terminally differentiated blood cell. Epigenetic silencing is critical for this process by regulating the transcription of cell-cycle genes critical for self-renewal and differentiation, as well as restricting alternative fate genes to allow lineage commitment and appropriate differentiation. There are two distinct forms of transcriptionally repressed chromatin: H3K9me3-marked heterochromatin and H3K27me3/H2AK119ub1-marked Polycomb (often referred to as facultative heterochromatin). This review will discuss the role of these distinct epigenetic silencing mechanisms in regulating normal haematopoiesis, how these contribute to age-related haematopoietic dysfunction, and the rationale for therapeutic targeting of these pathways in the treatment of haematological malignancies.
Identifiants
pubmed: 33929498
pii: 228480
doi: 10.1042/BST20200737
pmc: PMC8106494
doi:
Substances chimiques
Chromatin
0
Heterochromatin
0
Histones
0
Polycomb-Group Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
805-814Informations de copyright
© 2021 The Author(s).