Fibroblast growth factor 23 (FGF23) induces ventricular arrhythmias and prolongs QTc interval in mice in an FGF receptor 4-dependent manner.
Animals
Arrhythmias, Cardiac
/ metabolism
Calcium
/ metabolism
Electrocardiography
Fibroblast Growth Factor-23
Fibroblast Growth Factors
/ metabolism
Heart
/ drug effects
Heart Ventricles
/ drug effects
Isolated Heart Preparation
Long QT Syndrome
/ metabolism
Mice
Myocardium
/ metabolism
Myocytes, Cardiac
/ metabolism
Receptor, Fibroblast Growth Factor, Type 4
/ antagonists & inhibitors
Renal Insufficiency, Chronic
/ metabolism
Signal Transduction
Tachycardia, Ventricular
/ metabolism
Ventricular Premature Complexes
/ metabolism
calcium
cardiac function
chronic kidney disease
electrocardiogram
sudden cardiac death
Journal
American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
pubmed:
1
5
2021
medline:
24
7
2021
entrez:
30
4
2021
Statut:
ppublish
Résumé
Fibroblast growth factor 23 (FGF23) is a phosphate regulating protein hormone released by osteocytes. FGF23 becomes markedly elevated in chronic kidney disease (CKD), for which the leading cause of death is cardiovascular disease, particularly sudden cardiac death. Previously, we found that FGF23 increases intracellular Ca
Identifiants
pubmed: 33929896
doi: 10.1152/ajpheart.00798.2020
pmc: PMC8424547
doi:
Substances chimiques
Fgf23 protein, mouse
0
Fibroblast Growth Factors
62031-54-3
Fibroblast Growth Factor-23
7Q7P4S7RRE
Fgfr4 protein, mouse
EC 2.7.10.1
Receptor, Fibroblast Growth Factor, Type 4
EC 2.7.10.1
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
H2283-H2294Subventions
Organisme : HHS | National Institutes of Health (NIH)
ID : R01HL128714
Organisme : HHS | National Institutes of Health (NIH)
ID : R01HL145528
Organisme : NHLBI NIH HHS
ID : R01 HL128714
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK125459
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL145528
Pays : United States
Organisme : HHS | NIH | National Institute on Aging (NIA)
ID : P01AG039355
Organisme : NIA NIH HHS
ID : P01 AG039355
Pays : United States
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