CATMoS: Collaborative Acute Toxicity Modeling Suite.
Journal
Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
entrez:
30
4
2021
pubmed:
1
5
2021
medline:
26
11
2021
Statut:
ppublish
Résumé
Humans are exposed to tens of thousands of chemical substances that need to be assessed for their potential toxicity. Acute systemic toxicity testing serves as the basis for regulatory hazard classification, labeling, and risk management. However, it is cost- and time-prohibitive to evaluate all new and existing chemicals using traditional rodent acute toxicity tests. The U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Acute Toxicity Workgroup organized an international collaboration to develop An acute oral toxicity data inventory for 11,992 chemicals was compiled, split into training and evaluation sets, and made available to 35 participating international research groups that submitted a total of 139 predictive models. Predictions that fell within the applicability domains of the submitted models were evaluated using external validation sets. These were then combined into consensus models to leverage strengths of individual approaches. The resulting consensus predictions, which leverage the collective strengths of each individual model, form the Collaborative Acute Toxicity Modeling Suite (CATMoS). CATMoS demonstrated high performance in terms of accuracy and robustness when compared with CATMoS is being evaluated by regulatory agencies for its utility and applicability as a potential replacement for
Sections du résumé
BACKGROUND
Humans are exposed to tens of thousands of chemical substances that need to be assessed for their potential toxicity. Acute systemic toxicity testing serves as the basis for regulatory hazard classification, labeling, and risk management. However, it is cost- and time-prohibitive to evaluate all new and existing chemicals using traditional rodent acute toxicity tests.
OBJECTIVES
The U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Acute Toxicity Workgroup organized an international collaboration to develop
METHODS
An acute oral toxicity data inventory for 11,992 chemicals was compiled, split into training and evaluation sets, and made available to 35 participating international research groups that submitted a total of 139 predictive models. Predictions that fell within the applicability domains of the submitted models were evaluated using external validation sets. These were then combined into consensus models to leverage strengths of individual approaches.
RESULTS
The resulting consensus predictions, which leverage the collective strengths of each individual model, form the Collaborative Acute Toxicity Modeling Suite (CATMoS). CATMoS demonstrated high performance in terms of accuracy and robustness when compared with
DISCUSSION
CATMoS is being evaluated by regulatory agencies for its utility and applicability as a potential replacement for
Identifiants
pubmed: 33929906
doi: 10.1289/EHP8495
pmc: PMC8086800
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
47013Subventions
Organisme : NIEHS NIH HHS
ID : R43 ES031038
Pays : United States
Organisme : NIEHS NIH HHS
ID : HHSN273201500010C
Pays : United States
Organisme : NIGMS NIH HHS
ID : R44 GM122196
Pays : United States
Organisme : NIEHS NIH HHS
ID : R15 ES023148
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES016465
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES031080
Pays : United States
Commentaires et corrections
Type : ErratumIn
Type : ErratumIn
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